Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, 50-368, Wroclaw, Poland.
Centre of Diagnostic Imaging, 4Th Military Hospital, Weigla 5, 50-981, Wroclaw, Poland.
Cardiovasc Toxicol. 2021 Nov;21(11):869-879. doi: 10.1007/s12012-021-09677-8. Epub 2021 Jul 26.
The objective of our study was to determine the relationship between exposure to environmental tobacco smoke (ETS) and the value of the aortic valve calcification score (AVCS) in people suffering from arterial hypertension (AH). 107 non-smokers with AH (mean age 67.16 ± 8.48 years) were qualified for the study. The degree of exposure to ETS was assessed using the Second-hand Smoke Exposure Scale (SHSES) questionnaire. Study group was divided depending on ETS exposure: A-no exposure, B-low, C-medium and D-high. AVCS was measured based on the aortic valve plane multiplanar reconstruction from the non-contrast phase of the cardiac computed tomography. The Agatston algorithm was used, in which calcifications were considered changes with a density exceeding 130 HU. The mean AVCS value in the study group of patients was 213.59 ± 304.86. The AVCS was significantly lower in subgroup A than in subgroups C and D. In subgroup A, the lack of aortic valve calcification (AVCS = 0) was observed significantly more frequently than in subgroups C and D. There was a positive correlation between the number of SHSES points and the AVCS value (r = 0.37, p < 0.05). Based on the ROC curve, the SHSES value was determined as the optimal cut-off point for the prediction of AVCS = 0, amounting to 3 points. The accuracy of SHSES < 3 as the predictor of AVCS = 0 was set at 62.18%. Hypertensive patients have an unfavourable relationship between the amount of exposure to ETS, determined on the SHSES scale, and the AVCS value.
本研究旨在探讨环境烟草烟雾（ETS）暴露与动脉高血压（AH）患者主动脉瓣钙化评分（AVCS）值之间的关系。本研究纳入了 107 名非吸烟的 AH 患者（平均年龄 67.16±8.48 岁）。采用二手烟暴露量表（SHSES）问卷评估 ETS 暴露程度。根据 ETS 暴露程度将研究对象分为 A 组（无暴露）、B 组（低暴露）、C 组（中暴露）和 D 组（高暴露）。AVCS 值通过心脏 CT 非对比期的主动脉瓣平面多平面重建进行测量。采用 Agatston 算法，将密度超过 130 HU 的钙化视为病变。研究组患者的平均 AVCS 值为 213.59±304.86。与 C 组和 D 组相比，A 组的 AVCS 值明显较低。A 组中主动脉瓣无钙化（AVCS=0）的比例明显高于 C 组和 D 组。SHSES 评分与 AVCS 值呈正相关（r=0.37，p<0.05）。基于 ROC 曲线，SHSES 评分被确定为预测 AVCS=0 的最佳截断值，为 3 分。SHSES<3 预测 AVCS=0 的准确率为 62.18%。在 ETS 暴露量与 AVCS 值之间存在负相关关系。
