Kölbl H, Tatra G, Bieglmayer C
Universitätsfrauenklinik Wien.
Klin Wochenschr. 1987 Dec 1;65(23):1151-4. doi: 10.1007/BF01734839.
Serum levels of immunosuppressive acidic protein (IAP) were determined in 48 healthy controls (age: means = 37.8 +/- 13.8 years) and 72 pregnant women (age: means = 27.05 +/- 5.5 years). The mean value of IAP in pregnant women (345.3 +/- 94.4 micrograms/ml) was significantly lower than that of the healthy control group (P less than 0.0001; 452.0 +/- 95.0 micrograms/ml). Correlated to the clinical status were 207 IAP serum values of 63 patients with ovarian cancer (age: means = 56.9 +/- 11.1). The mean value of patients with tumor progression (means = 799.3 +/- 292.2 micrograms/ml) was significantly increased compared to those of patients in remission (means = 511.0 +/- 111.9 micrograms/ml) and the control group (means = 463 +/- 146.8 micrograms/ml; P less than 0.0001). However, no significant difference of the IAP levels was found between the group in remission and the healthy controls. With a threshold value of 640 micrograms/ml we found right-negative values in 88.7% and right-positive values in 65.1% during the follow-up of patients with ovarian cancer.
在48名健康对照者（年龄：平均37.8±13.8岁）和72名孕妇（年龄：平均27.05±5.5岁）中测定了免疫抑制酸性蛋白（IAP）的血清水平。孕妇IAP的平均值（345.3±94.4微克/毫升）显著低于健康对照组（P＜0.0001；452.0±95.0微克/毫升）。对63例卵巢癌患者（年龄：平均56.9±11.1岁）的207份IAP血清值与临床状况进行了相关性分析。肿瘤进展患者的平均值（平均799.3±292.2微克/毫升）与缓解期患者（平均511.0±111.9微克/毫升）及对照组（平均463±146.8微克/毫升；P＜0.0001）相比显著升高。然而，缓解期组与健康对照组之间IAP水平无显著差异。以640微克/毫升为阈值，在卵巢癌患者的随访中，我们发现真阴性值为88.7%，真阳性值为65.1%。
