Department of Radiotherapy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands.
Int J Numer Method Biomed Eng. 2021 Sep;37(9):e3512. doi: 10.1002/cnm.3512. Epub 2021 Aug 8.
To study the effects of the control temperature, ablation time, and the background tissue surrounding the tumor on the size of the ablation zone on radiofrequency ablation (RFA) of osteoid osteoma (OO). Finite element models of non-cooled temperature-controlled RFA of typical OOs were developed to determine the resulting ablation radius at control temperatures of 70, 80, and 90°C. Three different geometries were used, mimicking common cases of OO. The ablation radius was obtained by using the Arrhenius equation to determine cell viability. Ablation radii were larger for higher temperatures and also increased with time. All geometries and control temperatures tested had ablation radii larger than the tumor. The ablation radius developed rapidly in the first few minutes for all geometries and control temperatures tested, developing slowly towards the end of the ablation. Resistive heating and the temperature distribution showed differences depending on background tissue properties, resulting in differences in the ablation radius on each geometry. The ablation radius has a clear dependency not only on the properties of the tumor but also on the background tissue. Lower background tissue's electrical conductivity and blood perfusion rates seem to result in larger ablation zones. The differences observed between the different geometries suggest the need for patient-specific planning, as the anatomical variations could cause significantly different outcomes where models like the one here presented could help to guarantee safe and successful tumor ablations.
研究控制温度、消融时间以及肿瘤周围背景组织对骨样骨瘤（OO）射频消融（RFA）消融区域大小的影响。针对典型 OO 的非冷却温度控制 RFA 建立了有限元模型，以确定在 70、80 和 90°C 的控制温度下的相应消融半径。使用三种不同的几何形状模拟了常见的 OO 情况。通过使用阿累尼乌斯方程确定细胞活力来获得消融半径。较高的温度和较长的时间会导致消融半径增大。所有测试的几何形状和控制温度的消融半径都大于肿瘤。在测试的所有几何形状和控制温度下，消融半径在前几分钟迅速增加，接近消融结束时则缓慢增加。电阻加热和温度分布取决于背景组织特性，从而导致每个几何形状的消融半径不同。消融半径不仅取决于肿瘤的特性，还取决于背景组织。较低的背景组织电导率和血流灌注率似乎会导致更大的消融区域。不同几何形状之间观察到的差异表明需要进行患者特定的规划，因为解剖结构的变化可能会导致非常不同的结果，而这里提出的模型可以帮助确保安全有效的肿瘤消融。
