Department of Opthalmology, Kırşehir Training and Research Hospital, Kirsehir, Turkey.
Department of Cardiology, Kırşehir Training and Research Hospital, Kirsehir, Turkey.
Eur J Ophthalmol. 2022 Jul;32(4):2427-2432. doi: 10.1177/11206721211035615. Epub 2021 Jul 27.
To assess the impact of systemic hypertension on the choroidal structure and choroidal vascularity index (CVI).
This prospective cross-sectional study comprised 50 eyes of 50 treatment-naive hypertensive patients and 50 eyes of 50 healthy subjects. Choroidal thickness (CT) was measured in the subfoveal region, 1500 µm nasal to the fovea, and 1500 µm temporal to the fovea. Binarization of the enhanced depth-optical coherence tomography images was performed with Image-J software. The CT, choroidal area (CA), luminal area (LA), and CVI were compared statistically.
The mean subfoveal, nasal, and temporal CT were decreased in the patient group (p 0.003, 0.026, and 0.001, respectively). The mean CA, LA, and CVI were decreased in the patient group in comparison to controls ( = 0.047, 0.009, and 0.016 respectively). The correlation between the subfoveal CT and systolic blood pressure was significant ( = -0.450, < 0.001). There was a significant correlation between the systolic blood pressure and CVI ( = -0.401, < 0.001).
The significant decrease in the structural parameters and CVI show that choroid is affected in patients with treatment-naive hypertension.
评估系统性高血压对脉络膜结构和脉络膜血流指数（CVI）的影响。
本前瞻性横断面研究纳入了 50 例未经治疗的高血压患者的 50 只眼和 50 例健康受试者的 50 只眼。在黄斑下、黄斑鼻侧 1500μm 处和黄斑颞侧 1500μm 处测量脉络膜厚度（CT）。使用 Image-J 软件对增强深度光学相干断层扫描图像进行二值化。对 CT、脉络膜面积（CA）、管腔面积（LA）和 CVI 进行统计学比较。
与对照组相比，患者组的黄斑下、黄斑鼻侧和黄斑颞侧 CT 平均值均降低（p 值分别为 0.003、0.026 和 0.001）。与对照组相比，患者组的 CA、LA 和 CVI 平均值均降低（ = 0.047、0.009 和 0.016）。黄斑下 CT 与收缩压之间存在显著相关性（ = -0.450， < 0.001）。收缩压与 CVI 之间存在显著相关性（ = -0.401， < 0.001）。
结构参数和 CVI 的显著降低表明未经治疗的高血压患者的脉络膜受到了影响。
