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Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane.

作者信息

Frank H, Wiegand M, Strecker M, Thiel D

机构信息

Institut fuer Toxikologie, Universitaet Tuebingen, Federal Republic of Germany.

出版信息

Lipids. 1987 Oct;22(10):689-97. doi: 10.1007/BF02533967.

DOI:10.1007/BF02533967
PMID:3431344
Abstract

An accurate method for the quantitative determination of hydroperoxy and hydroxy fatty acids in liver microsomes is presented which involves the use of 18O-labeled internal standards. The method is employed for the determination of hydroperoxides in rat liver microsomes after aerobic incubation with Fe2+/ADP and in microsomes from animals exposed to 75 mg tetrachloromethane/kg body weight. The amounts found after artificial microsomal "lipid peroxidation" are almost two orders of magnitude larger than those in microsomes from tetrachloromethane-exposed animals.

摘要

相似文献

1
Monohydroperoxides of linoleic acid in endoplasmic lipids of rats exposed to tetrachloromethane.
Lipids. 1987 Oct;22(10):689-97. doi: 10.1007/BF02533967.
2
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本文引用的文献

1
Peroxidation of subcellular organelles: formation of lipofuscinlike fluorescent pigments.亚细胞器的过氧化作用：脂褐素样荧光色素的形成。
Science. 1969 Dec 19;166(3912):1535-6. doi: 10.1126/science.166.3912.1535.
2
The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.硫代巴比妥酸试剂用于检测各种试剂对不饱和脂肪酸的氧化作用。
Arch Biochem. 1949 Dec;24(2):305-13.
3
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.肝微粒体的一氧化碳结合色素。II. 增溶、纯化及性质
J Biol Chem. 1964 Jul;239:2379-85.
4
Enhanced lipid peroxidation in liver microsomes of zinc-deficient rats.缺锌大鼠肝脏微粒体中脂质过氧化作用增强。
Am J Clin Nutr. 1980 Jan;33(1):51-6. doi: 10.1093/ajcn/33.1.51.
5
Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides.从猪肝中纯化出一种蛋白质，该蛋白质可保护脂质体和生物膜免受过氧化降解，并对磷脂酰胆碱氢过氧化物表现出谷胱甘肽过氧化物酶活性。
Biochim Biophys Acta. 1982 Feb 15;710(2):197-211. doi: 10.1016/0005-2760(82)90150-3.
6
Organ chemiluminescence: noninvasive assay for oxidative radical reactions.有机化学发光：氧化自由基反应的非侵入性检测方法。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):347-51. doi: 10.1073/pnas.77.1.347.
7
High-performance liquid chromatography and gas chromatography-mass spectrometry determination of specific lipid peroxidation products in vivo.高效液相色谱法和气相色谱-质谱联用法定量测定体内特定脂质过氧化产物
Anal Biochem. 1983 Apr 15;130(2):431-6. doi: 10.1016/0003-2697(83)90612-7.
8
The influence of phospholipase A2 and glutathione peroxidase on the elimination of membrane lipid peroxides.磷脂酶A2和谷胱甘肽过氧化物酶对膜脂质过氧化物清除的影响。
Arch Biochem Biophys. 1983 Jun;223(2):441-52. doi: 10.1016/0003-9861(83)90608-2.
9
Lipid peroxidation as a possible cause of TCDD toxicity.
Biochem Biophys Res Commun. 1983 Mar 29;111(3):854-9. doi: 10.1016/0006-291x(83)91377-3.
10
Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation.过氧化氢对微粒体脂质过氧化起始的影响。
Biochem Pharmacol. 1983 Jan 1;32(1):123-7. doi: 10.1016/0006-2952(83)90663-9.