神经生物学：重置轴突的“电池”。
Neurobiology: Resetting the axon's batteries.
机构信息
Department of Biological Sciences, University of South Carolina, Columbia, SC 20208, USA.
Department of Biology, Ball State University, Muncie, IN 47306, USA.
出版信息
Curr Biol. 2021 Jul 26;31(14):R914-R917. doi: 10.1016/j.cub.2021.06.014.
Abstract
Neuronal injury can cause mitochondrial damage, leading to reduced energy production, decreased Ca storage capacity, and increased reactive oxygen species. A new study reveals a mechanism to trigger the axonal transport of previously anchored mitochondria and promote neuroprotection and axon regeneration by replacing damaged with functional mitochondria.
摘要
神经元损伤可导致线粒体损伤，使能量产生减少、钙储存能力降低、活性氧增加。一项新的研究揭示了一种触发先前锚定的线粒体轴突运输的机制，通过用功能正常的线粒体替代受损的线粒体，从而促进神经保护和轴突再生。
相似文献
1
Neurobiology: Resetting the axon's batteries.神经生物学：重置轴突的“电池”。
Curr Biol. 2021 Jul 26;31(14):R914-R917. doi: 10.1016/j.cub.2021.06.014.
2
Mitochondrial behavior during axon regeneration/degeneration in vivo.体内轴突再生/退化过程中的线粒体行为。
Neurosci Res. 2019 Feb;139:42-47. doi: 10.1016/j.neures.2018.08.014. Epub 2018 Sep 1.
3
Mitochondria Localize to Injured Axons to Support Regeneration.线粒体定位于受损轴突以支持再生。
Neuron. 2016 Dec 21;92(6):1308-1323. doi: 10.1016/j.neuron.2016.11.025.
4
The role of stretching in slow axonal transport.拉伸在缓慢轴突运输中的作用。
Biophys J. 2011 Jan 19;100(2):351-60. doi: 10.1016/j.bpj.2010.12.3695.
5
Accuracy of reinnervation by peripheral nerve axons regenerating across a 10-mm gap within an impermeable chamber.
Exp Neurol. 1991 Mar;111(3):332-9. doi: 10.1016/0014-4886(91)90100-q.
6
Neuronal Intrinsic Regenerative Capacity: The Impact of Microtubule Organization and Axonal Transport.神经元内在再生能力：微管组织和轴突运输的影响。
Dev Neurobiol. 2018 Oct;78(10):952-959. doi: 10.1002/dneu.22602. Epub 2018 May 8.
7
Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders.线粒体运输作为轴突中线粒体质量控制策略：对中枢神经系统疾病的影响。
CNS Neurosci Ther. 2019 Jul;25(7):876-886. doi: 10.1111/cns.13122. Epub 2019 Mar 21.
8
Increased ER-mitochondria tethering promotes axon regeneration.内质网-线粒体连接增加促进轴突再生。
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16074-16079. doi: 10.1073/pnas.1818830116. Epub 2019 Jul 22.
9
The role of mitochondria in axon development and regeneration.线粒体在轴突发育和再生中的作用。
Dev Neurobiol. 2018 Mar;78(3):221-237. doi: 10.1002/dneu.22546. Epub 2017 Oct 24.
10
The Virtuous Cycle of Axon Growth: Axonal Transport of Growth-Promoting Machinery as an Intrinsic Determinant of Axon Regeneration.轴突生长的良性循环：促进生长的机制的轴突运输作为轴突再生的内在决定因素。
Dev Neurobiol. 2018 Oct;78(10):898-925. doi: 10.1002/dneu.22608. Epub 2018 Jul 10.
引用本文的文献
1
Mitochondrial dynamics reveal potential to facilitate axonal regeneration after spinal cord injury.线粒体动力学显示出促进脊髓损伤后轴突再生的潜力。
J Transl Med. 2025 Jun 2;23(1):617. doi: 10.1186/s12967-025-06611-2.
2
Environmental enrichment promotes functional recovery from stroke via enhancing neuroplasticity through the action of -HB.环境富集通过-HB的作用增强神经可塑性，从而促进中风后的功能恢复。
J Cereb Blood Flow Metab. 2025 May 15:271678X251328179. doi: 10.1177/0271678X251328179.
3
The Role of PGC-1α-Mediated Mitochondrial Biogenesis in Neurons.PGC-1α 介导的线粒体生物发生在神经元中的作用。
Neurochem Res. 2023 Sep;48(9):2595-2606. doi: 10.1007/s11064-023-03934-8. Epub 2023 Apr 25.
本文引用的文献
1
Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia.重编程活跃的 AKT-PAK5 轴可增强轴突的能量供应，并促进损伤和缺血后的神经元存活和再生。
Curr Biol. 2021 Jul 26;31(14):3098-3114.e7. doi: 10.1016/j.cub.2021.04.079. Epub 2021 Jun 3.
2
The functional organization of axonal mRNA transport and translation.轴突 mRNA 运输和翻译的功能组织。
Nat Rev Neurosci. 2021 Feb;22(2):77-91. doi: 10.1038/s41583-020-00407-7. Epub 2020 Dec 7.
3
Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury.恢复细胞能量代谢促进脊髓损伤后轴突再生和功能恢复。
Cell Metab. 2020 Mar 3;31(3):623-641.e8. doi: 10.1016/j.cmet.2020.02.002.
4
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.RNA 颗粒借助溶酶体进行长距离运输，利用膜联蛋白 A11 作为分子连接物。
Cell. 2019 Sep 19;179(1):147-164.e20. doi: 10.1016/j.cell.2019.08.050.
5
Autophagy in Neurons.神经元自噬。
Annu Rev Cell Dev Biol. 2019 Oct 6;35:477-500. doi: 10.1146/annurev-cellbio-100818-125242. Epub 2019 Jul 23.
6
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.HDAC6 通过去乙酰化 Miro1 阻断线粒体运输并介导轴突生长抑制。
J Cell Biol. 2019 Jun 3;218(6):1871-1890. doi: 10.1083/jcb.201702187. Epub 2019 May 8.
7
Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.晚期内体充当 mRNA 翻译平台并维持轴突中的线粒体。
Cell. 2019 Jan 10;176(1-2):56-72.e15. doi: 10.1016/j.cell.2018.11.030. Epub 2019 Jan 3.
8
Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity.空间稳定的线粒体隔室为可塑性期间的局部翻译提供燃料。
Cell. 2019 Jan 10;176(1-2):73-84.e15. doi: 10.1016/j.cell.2018.12.013. Epub 2019 Jan 3.
9
A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity.高线粒体转运速率是具有高轴突再生能力的中枢神经系统神经元的特征。
PLoS One. 2017 Sep 19;12(9):e0184672. doi: 10.1371/journal.pone.0184672. eCollection 2017.
10
Nuclear-Encoded Mitochondrial mRNAs: A Powerful Force in Axonal Growth and Development.核编码的线粒体 mRNAs：轴突生长和发育的强大力量。
Neuroscientist. 2018 Apr;24(2):142-155. doi: 10.1177/1073858417714225. Epub 2017 Jun 14.
Zotero 插件