State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, PR China.
University of Science and Technology of China, Hefei 230026, PR China.
ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56873-56880. doi: 10.1021/acsami.1c16366. Epub 2021 Nov 19.
A cubic porphyrin-based covalent organic framework (COF) named CTP with excellent hydrophilicity was prepared with a facile method for the first time. Different from the conventional methods for the synthesis of porphyrin-based COFs, this facile strategy has greatly shortened the reaction time under mild conditions. Linking the porphyrin monomer into the COF overcame its poor solubility and biocompatibility and also narrowed the band gap owing to the formation of the π-conjugation structure. The improved biocompatibility and narrowed band gap enabled CTP to be an excellent sonosensitizer with an enhanced sonodynamic effect. Moreover, CTP could also effectively realize photothermal conversion under external irradiation due to the extended conjugated structure. This work developed a novel synthesis method for COFs and employed a COF as a sonosensitizer for the first time, which not only provided a new strategy to improve the efficiency of organic sonosensitizers but also inspired us to design more functional COFs for versatile applications.
首次采用简便的方法制备了一种具有优异亲水性的基于立方卟啉的共价有机骨架（COF），命名为 CTP。与传统的基于卟啉的 COF 合成方法不同，这种简便的策略在温和条件下大大缩短了反应时间。将卟啉单体连接到 COF 中克服了其较差的溶解度和生物相容性，并由于形成了π共轭结构而缩小了带隙。提高的生物相容性和缩小的带隙使 CTP 成为一种出色的声敏剂，具有增强的声动力学效应。此外，由于扩展的共轭结构，CTP 还可以在外照射下有效实现光热转换。这项工作为 COFs 开发了一种新的合成方法，并首次将 COF 用作声敏剂，不仅为提高有机声敏剂的效率提供了新策略，也启发我们设计更多功能的 COFs 以实现多功能应用。
