College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China.
Chem Commun (Camb). 2021 Aug 28;57(67):8320-8323. doi: 10.1039/d1cc02102h. Epub 2021 Jul 28.
Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the "opened" form (OF) of DAE-TPE NPs was converted to the "closed" form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.
本文开发了一种基于二芳基乙烯衍生物 DAE-TPE 的光活化光敏剂用于光动力疗法。在紫外光照射下，DAE-TPE NPs 的“开环”形式（OF）转化为“闭环”形式（CF），并激活光敏化作用。DAE-TPE NPs 的 CF 对 HeLa 细胞表现出足够的光动力治疗效果。
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