Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
J Exp Med. 2021 Sep 6;218(9). doi: 10.1084/jem.20211348. Epub 2021 Jul 28.
The NS1 protein of flaviviruses is taking center stage. Recent work has made it an attractive target for development of vaccines and immunotherapeutics. Cavazzoni and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210580) now reveal a dark side to NS1, linking it to the development of self-reactive antibodies.
黄病毒的 NS1 蛋白正成为关注焦点。最近的研究使其成为疫苗和免疫疗法开发的一个有吸引力的靶点。Cavazzoni 及其同事（2021. J. Exp. Med. https://doi.org/10.1084/jem.20210580）现在揭示了 NS1 的一个阴暗面，将其与自身反应性抗体的产生联系起来。
