Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
Cell Rep. 2021 Jul 27;36(4):109437. doi: 10.1016/j.celrep.2021.109437.
The dorsal striatum plays a central role in the selection, execution, and evaluation of actions. An emerging model attributes action selection to the matrix and evaluation to the striosome compartment. Here, we use large-scale cell-type-specific calcium imaging to determine the activity of striatal projection neurons (SPNs) during motor and decision behaviors in the three major outputs of the dorsomedial striatum: Oprm1 striosome versus D1 direct and A2A indirect pathway SPNs. We find that Oprm1 SPNs show complex tunings to simple movements and value-guided actions, which are conserved across many sessions in a single task but remap between contexts. During decision making, the SPN tuning profiles form a complete representation in which sequential SPN activity jointly encodes task progress and value. We propose that the three major output pathways in the dorsomedial striatum share a similarly complete representation of the entire action space, including task- and phase-specific signals of action value and choice.
背侧纹状体在动作的选择、执行和评估中起着核心作用。一个新兴的模型将动作选择归因于基质，将评估归因于纹状体隔区。在这里，我们使用大规模的细胞类型特异性钙成像来确定背侧纹状体的三个主要输出中的运动和决策行为期间纹状体投射神经元（SPN）的活动：Oprm1 纹状体与 D1 直接和 A2A 间接途径 SPN。我们发现 Oprm1 SPN 对简单运动和价值引导的动作表现出复杂的调谐，这种调谐在单个任务的许多会话中都是保守的，但在不同的环境中会重新映射。在决策过程中，SPN 的调谐曲线形成了一个完整的表示，其中连续的 SPN 活动共同编码任务进度和价值。我们提出，背侧纹状体的三个主要输出途径共享整个动作空间的类似完整表示，包括动作价值和选择的任务和相位特异性信号。
