美容院工作女性尿中未代谢对羟基苯甲酸酯水平。
Urinary level of un-metabolized parabens in women working in beauty salons.
机构信息
Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran; Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran; Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
出版信息
Environ Res. 2021 Sep;200:111771. doi: 10.1016/j.envres.2021.111771. Epub 2021 Jul 26.
Parabens are a group of chemical additive extensively utilized in various health care products and ubiquitously observed in the different environmental matrixes. Nevertheless, the exposure of women working in beauty salons to these pollutants is not well-documented. For this purpose, 50.00 women working in beauty salons were chosen as the exposed group (EG) and 35.00 housewives were chosen as the control group (GC). The concentration of methyl paraben (MeP), ethyl paraben (EtP), butyl paraben (BuP), propyl paraben (PrP), benzyl paraben (BzP), heptyl paraben (HepP), and para-hydroxybenzoic acid (4-HB) metabolite were quantified in the collected urine samples. It was seen that paraben sexist with a high detection frequency (DF) in the urine of women working in beauty salons. The results also revealed that the significant difference between the urinary parabens level in the EG and CG (P value < 0.05). The median concentration of Σparaben and HB-4 metabolite in the before exposure (BE) samples was 124.00 and 219.00 μg/L, while in the after exposure (AE) samples, it was 156.00 and 249.00 μg/L, respectively. Moreover, the parabens levels in the AE samples were considerably higher than in BE samples in women working in beauty salons (P value < 0.05). This research also documented that "personal care products (PCPs) usage" can be known as a leading factor for the urinary paraben level in the studied individuals. The median total estimated daily intakes (TEsDI) for MeP, EtP, and PrP for the studied women were obtained as 8.02, 4.57, and 7.88 μg/L respectively. Also, a significant and positive association was observed between EtP, PrP as well as BuP and 8-OhdG (as a DNA oxidative stress biomarker) (P value < 0.01). Further, a significant and positive association was found between EtP as well as BuP and some biomarkers of kidney damage (like uTIMP-1 and uKim-1). Accordingly, it can be stated that women working in beauty salons are at a high risk in terms of DNA oxidative stress and kidney damage.
对苯二甲酸酯是一组广泛应用于各种保健产品的化学添加剂，在各种环境基质中都有发现。然而，目前对于在美容院工作的女性接触这些污染物的情况并没有很好的记录。为此，选择了 50 名在美容院工作的女性作为暴露组（EG），35 名家庭主妇作为对照组（GC）。收集了她们的尿液样本，并定量检测了其中的甲基对苯二甲酸酯（MeP）、乙基对苯二甲酸酯（EtP）、丁基对苯二甲酸酯（BuP）、丙基对苯二甲酸酯（PrP）、苄基对苯二甲酸酯（BzP）、庚基对苯二甲酸酯（HepP）和对羟基苯甲酸（4-HB）代谢物的浓度。结果显示，在美容院工作的女性尿液中存在多种高检测频率（DF）的对苯二甲酸酯。研究结果还表明，EG 和 CG 之间尿液中对苯二甲酸酯水平存在显著差异（P 值<0.05）。暴露前（BE）样本中Σ对苯二甲酸酯和 HB-4 代谢物的中位数浓度分别为 124.00 和 219.00μg/L，而暴露后（AE）样本中的浓度分别为 156.00 和 249.00μg/L。此外，美容院工作的女性 AE 样本中的对苯二甲酸酯水平明显高于 BE 样本（P 值<0.05）。研究还记录了“个人护理产品（PCPs）的使用”可被视为研究个体尿液中对苯二甲酸酯水平的一个主要因素。研究中女性的甲基对苯二甲酸酯（MeP）、乙基对苯二甲酸酯（EtP）和丙基对苯二甲酸酯（PrP）的总估计每日摄入量（TEsDI）中位数分别为 8.02、4.57 和 7.88μg/L。此外，还观察到 EtP、PrP 以及 BuP 与 8-OhdG（一种 DNA 氧化应激生物标志物）之间存在显著正相关（P 值<0.01）。此外，还发现 EtP 和 BuP 与一些肾脏损伤的生物标志物（如 uTIMP-1 和 uKim-1）之间存在显著正相关。因此，可以说在美容院工作的女性面临着 DNA 氧化应激和肾脏损伤的高风险。
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