Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Egypt.
J Chem Neuroanat. 2021 Nov;117:102006. doi: 10.1016/j.jchemneu.2021.102006. Epub 2021 Jul 26.
Nowadays, Covid-19 is considered a serious health problem worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that has sparked a global pandemic of the coronavirus disease of 2019 (COVID-19). It is well known that the Corona Virus attacks mainly the respiratory system. Meanwhile, it has been established that coronavirus infection can extend beyond the respiratory system and unfortunately, can also affect our nervous system. Multiple neurological symptoms and signs had been documented during and post covid conditions. This virus gets access to the central nervous system (CNS) via the bloodstream leading to infect the endothelial lining cells. Also, it was reported that the virus can enter the peripheral nervous system via retrograde neuronal routes. The virus could be internalized in nerve synapses through endocytosis, transported retrogradely, and spread trans-synoptically to other brain regions. This minireview highlights the possible routes by which SARS-CoV-2 can invade the central nervous system (CNS) and its pathophysiology and manifestation.
如今，Covid-19 被认为是全球范围内的严重健康问题。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是一种新型人类冠状病毒，引发了 2019 年冠状病毒病（COVID-19）的全球大流行。众所周知，冠状病毒主要攻击呼吸系统。同时，已经确定冠状病毒感染不仅限于呼吸系统，而且还会不幸地影响我们的神经系统。在新冠病毒感染期间和之后，已经记录了多种神经系统症状和体征。该病毒通过血液进入中枢神经系统（CNS），导致感染血管内皮细胞。此外，据报道，病毒可以通过逆行神经元途径进入周围神经系统。病毒可以通过内吞作用在内神经突触中内化，逆行运输，并在突触间传播到其他大脑区域。这篇迷你综述强调了 SARS-CoV-2 侵入中枢神经系统（CNS）及其病理生理学和表现的可能途径。
