Amity Institute of Pharmacy, Amity University, Noida, UP 201303, India.
College of Science, Department of Medical Laboratory Sciences, Al-Balqa' Applied University, Salt, Jordan.
Curr Drug Metab. 2021;22(12):918-930. doi: 10.2174/1389200222666210729114456.
Obesity is a major lifestyle disorder, and it is correlated with several ailments. The prevalence of obesity has elevated over the years, and it has become a global health problem. The drugs presently used for managing obesity have several side effects, such as diarrhea, leakage of oily stools, etc. On the contrary, herbal plants and natural products are considered safe for use because they have lesser side effects. New compounds isolated from medicinal plants are screened and identified to determine their effectiveness and potential in preventing abnormal weight gain. In this review, the medicinal plants and natural materials are surveyed across the literature to cover those that have the potential for managing and controlling weight gain. Furthermore, their mechanism of action, active components, and experimental methodologies are also reviewed. These herbal products can be developed as formulations for therapeutic use in obesity. The herbal plants mentioned in the review are classified based on their mechanism of action, inhibition of pancreatic lipase, and appetite suppression activities. The ability to inhibit pancreatic lipase enzyme has been used to determine the effectiveness of herbal products for the prevention of abnormal weight gain because of its action on dietary fat and suppression of appetite. This review is an attempt to summarize the herbal plants and natural products that can be used to develop formulations effective in controlling weight gain and obesity.
肥胖是一种主要的生活方式障碍，与多种疾病相关。肥胖的患病率多年来一直在上升，已成为全球性的健康问题。目前用于治疗肥胖的药物有许多副作用，如腹泻、油性粪便泄漏等。相比之下，草药和天然产品被认为使用安全，因为它们的副作用较小。从药用植物中分离出的新化合物经过筛选和鉴定，以确定它们在预防体重异常增加方面的有效性和潜力。在这篇综述中，对文献中涉及的药用植物和天然材料进行了调查，以涵盖那些具有管理和控制体重增加潜力的材料。此外，还综述了它们的作用机制、活性成分和实验方法。这些草药产品可以开发成治疗肥胖的配方。综述中提到的草药植物根据其作用机制、抑制胰脂肪酶和抑制食欲活性进行分类。抑制胰脂肪酶的能力已被用于确定草药产品预防体重异常增加的有效性，因为它作用于膳食脂肪并抑制食欲。本综述试图总结可用于开发控制体重增加和肥胖的有效配方的草药植物和天然产品。
