Ettehad-Marvasti Fateme, Ejtahed Hanieh-Sadat, Siadat Seyed-Davar, Soroush Ahmad-Reza, Hoseini-Tavassol Zahra, Hasani-Ranjbar Shirin, Larijani Bagher
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Front Nutr. 2022 Oct 24;9:1007506. doi: 10.3389/fnut.2022.1007506. eCollection 2022.
From a nutritional perspective, garlic extract could be a prebiotic product, which is useful for obese subjects, and one of its health-promoting underlying mechanisms is modulating gut microbiota composition. In this randomized double-blind clinical trial, the goal was to determine the effect of (garlic extract) on anthropometric indices and gut microbiota composition in obese women following a low-calorie diet.
Forty-three obese women were randomly divided into garlic extract (400 mg powder containing 1,100 mcg allicin/tablet) or placebo groups. During the 2 months of the study, each participant took two tablets per day. At the beginning and at the end of the clinical trial, anthropometric measurements were done and blood and fecal samples were collected. We evaluated the gut microbiota composition using quantitative real-time PCR.
In total, 16 subjects in each group completed the 2-month trial. Allium and placebo groups' participants had mean ages of 37.8 ± 7.4 and 34.2 ± 6.8 years, respectively ( > 0.05). Baseline body mass index (BMI) was significantly different between groups, subjects in the placebo group had lower BMI compared with the Allium group ( < 0.05). and placebo caused a 1.7% and 2.7% decrease in BMI from the baseline values, respectively ( < 0.01). Fasting insulin level significantly decreased in the both groups ( < 0.01). Level of homeostasis model assessment of insulin resistance (HOMA-IR) has decreased significantly in the Allium group ( = 0.007). The frequency of had decreasing trend while the abundance of and showed increasing trend in the Allium group.
In the both groups, a decrease in BMI and other anthropometric indices has been observed. Despite weight loss after following a low-calorie diet and taking , slight changes have been shown in the composition of gut microbiota in obese women.
This trial was registered in the Iranian Registry of Clinical Trials (IRCT) (code: IRCT090420001825N2).
从营养角度来看，大蒜提取物可能是一种益生元产品，对肥胖者有益，其促进健康的潜在机制之一是调节肠道微生物群组成。在这项随机双盲临床试验中，目的是确定大蒜提取物对低热量饮食的肥胖女性人体测量指标和肠道微生物群组成的影响。
43名肥胖女性被随机分为大蒜提取物组（每片含400毫克粉末，其中大蒜素1100微克）或安慰剂组。在研究的2个月期间，每位参与者每天服用两片。在临床试验开始和结束时，进行人体测量，并采集血液和粪便样本。我们使用定量实时PCR评估肠道微生物群组成。
每组共有16名受试者完成了为期2个月的试验。大蒜组和安慰剂组参与者的平均年龄分别为37.8±7.4岁和34.2±6.8岁（P>0.05）。两组的基线体重指数（BMI）有显著差异，安慰剂组受试者的BMI低于大蒜组（P<0.05）。大蒜提取物和安慰剂使BMI分别较基线值下降了1.7%和2.7%（P<0.01）。两组的空腹胰岛素水平均显著下降（P<0.01）。大蒜组的胰岛素抵抗稳态模型评估（HOMA-IR）水平显著下降（P=0.007）。大蒜组中，大肠杆菌的频率呈下降趋势，而双歧杆菌和拟杆菌的丰度呈上升趋势。
两组均观察到BMI和其他人体测量指标下降。尽管低热量饮食并服用大蒜提取物后体重减轻，但肥胖女性的肠道微生物群组成仅出现了轻微变化。
本试验已在伊朗临床试验注册中心（IRCT）注册（代码：IRCT090420001825N2）。
