基于 SUMO 的同源重组调控的研究进展。
Advances in SUMO-based regulation of homologous recombination.
机构信息
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Curr Opin Genet Dev. 2021 Dec;71:114-119. doi: 10.1016/j.gde.2021.07.007. Epub 2021 Jul 30.
Abstract
Homologous Recombination (HR) is a critical DNA repair mechanism for a range of genome lesions. HR is responsible for mending DNA double strand breaks (DSBs) using intact template DNA. In addition, many HR proteins help cope with DNA lesions generated from DNA replication and telomere deficiency. The functions of HR proteins are often regulated by protein modifications that can quickly and reversibly adjust substrate proteins' attributes. Sumoylation is one of the prevalent modifications that affects all steps of the HR processes and exerts diverse regulation on substrates. This review aims to summarize the most recent advances in our understanding of SUMO-based HR regulation and highlight some key questions that remain to be elucidated.
摘要
同源重组（HR）是一种针对多种基因组损伤的关键 DNA 修复机制。HR 负责使用完整的模板 DNA 修复 DNA 双链断裂（DSBs）。此外，许多 HR 蛋白有助于应对由 DNA 复制和端粒缺陷产生的 DNA 损伤。HR 蛋白的功能通常受到蛋白修饰的调节，这些修饰可以快速且可逆地调整底物蛋白的属性。SUMO 化是一种普遍的修饰方式，它影响 HR 过程的所有步骤，并对底物产生多样化的调控。本综述旨在总结我们对基于 SUMO 的 HR 调控的最新认识，并强调一些仍有待阐明的关键问题。
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