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脑卒中线粒体自噬机制的研究进展

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke.

作者信息

Lei Li, Yang Shuaifeng, Lu Xiaoyang, Zhang Yongfa, Li Tao

机构信息

Department of Neurosurgery, The First People's Hospital of Yunnan Province (Kunhua Hospital/The Affiliated Hospital of Kunming University of Science and Technology), Kunming, China.

Translational Neurosurgery and Neurobiology, University Hospital Aachen, RWTH Aachen, Aachen, Germany.

出版信息

Front Aging Neurosci. 2021 Jul 15;13:698601. doi: 10.3389/fnagi.2021.698601. eCollection 2021.

DOI:10.3389/fnagi.2021.698601
PMID:34335233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8319822/
Abstract

Mitochondrial autophagy is an early defense and protection process that selectively clears dysfunctional or excessive mitochondria through a distinctive mechanism to maintain intracellular homeostasis. Mitochondrial dysfunction during cerebral stroke involves metabolic disbalance, oxidative stress, apoptosis, endoplasmic reticulum stress, and abnormal mitochondrial autophagy. This article reviews the research progress on the mechanism of mitochondrial autophagy in ischemic stroke to provide a theoretical basis for further research on mitochondrial autophagy and the treatment of ischemic stroke.

摘要

线粒体自噬是一种早期防御和保护过程，通过独特机制选择性清除功能失调或过多的线粒体，以维持细胞内稳态。脑卒 中期间的线粒体功能障碍涉及代谢失衡、氧化应激、细胞凋亡、内质网应激以及异常的线粒体自噬。本文综述了缺血性 脑卒中中线粒体自噬机制的研究进展，为进一步研究线粒体自噬及缺血性脑卒中的治疗提供理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c922/8319822/7570825a614d/fnagi-13-698601-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c922/8319822/356d1ac5fb16/fnagi-13-698601-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c922/8319822/7570825a614d/fnagi-13-698601-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c922/8319822/356d1ac5fb16/fnagi-13-698601-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c922/8319822/7570825a614d/fnagi-13-698601-g0002.jpg

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