Tulek Amela, Mulic Aida, Runningen Maria, Lillemo Jannike, Utheim Tor Paaske, Khan Qalbi, Sehic Amer
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Nordic Institute of Dental Materials (NIOM), Oslo, Norway.
Int J Dent. 2021 Jul 12;2021:5566733. doi: 10.1155/2021/5566733. eCollection 2021.
The present review aims to give an overview of the literature focusing on novel genetic aspects of dental erosion and dental caries. Once the tooth erupts into the oral cavity, the regenerative capability of enamel is fundamentally limited due to the loss of dental epithelium during eruption. The susceptibility or resistance to dental erosion and caries is presumably a result of environmental, phenotypic, and/or genetic influence. Even though it is evident that individuals frequently exposing their teeth to acid and sugar are at high risk of developing dental erosion and caries, the findings exclusively based on these factors are elusive. . The present review was based on data collected from the National Library of Medicine database with different combinations of the following terms: "tooth," "dental," "dentin," "enamel," "erosion," "erosive wear," "caries," "decay," "gene," and "genetic." A total of forty-six studies met the inclusion criteria. Data were extracted by one reviewer and verified by another.
The high prevalence of erosion and caries among certain groups, and observations that not all individuals appearing to be at risk develop these lesions, has sparked research on identifying genetic effects to these conditions. A connection of genome-wide and candidate gene studies has increased considerably in the literature. This review reveals largely varying success among studies, demonstrating the difficulties of developing the study with adequate sample sizes and durable phenotype definitions that permit enough statistical power to identify genetic contributors.
本综述旨在概述聚焦于牙侵蚀和龋齿新遗传方面的文献。牙齿萌出到口腔后，由于萌出过程中牙上皮的丧失，釉质的再生能力从根本上受到限制。对牙侵蚀和龋齿的易感性或抵抗力可能是环境、表型和/或遗传影响的结果。尽管很明显，经常使牙齿暴露于酸和糖的个体患牙侵蚀和龋齿的风险很高，但仅基于这些因素的研究结果并不明确。本综述基于从美国国立医学图书馆数据库收集的数据，这些数据使用了以下术语的不同组合：“牙齿”“牙”“牙本质”“釉质”“侵蚀”“侵蚀性磨损”“龋齿”“龋坏”“基因”和“遗传”。共有46项研究符合纳入标准。数据由一名审阅者提取，并由另一名审阅者核实。
某些群体中侵蚀和龋齿的高患病率，以及并非所有看似有风险的个体都会出现这些病变的观察结果，引发了对确定这些情况遗传影响的研究。文献中全基因组研究和候选基因研究之间的联系已大幅增加。本综述揭示了各研究结果差异很大，表明开展样本量充足且有持久表型定义、具备足够统计效力以识别遗传因素的研究存在困难。
