Flemming Jasmin, Hannig Christian, Hannig Matthias
Clinic of Operative Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, D-66424 Homburg, Germany.
J Clin Med. 2022 Nov 28;11(23):7044. doi: 10.3390/jcm11237044.
Bioadhesion and surface interactions on enamel are of essential relevance for initiation, progression and prevention of caries and erosions. Salivary proteins on and within initial carious and erosive lesions can facilitate or aggravate de- and remineralization. This applies for the pellicle layer, the subsurface pellicle and for proteins within initial carious lesions. Little is known about these proteinaceous structures related to initial caries and erosion. Accordingly, there is a considerable demand for an understanding of the underlying processes occurring at the interface between the tooth surface and the oral cavity in order to develop novel agents that limit and modulate caries and erosion. Objectives and findings: The present paper depicts the current knowledge of the processes occurring at the interface of the tooth surface and the oral fluids. Proteinaceous layers on dental hard tissues can prevent or aggravate demineralization processes, whereas proteins within initial erosive or carious lesions might hinder remineralization considerably and restrict the entry of ions into lesions.
Despite the fact that organic-inorganic surface interactions are of essential relevance for de- and remineralization processes at the tooth surface, there is limited knowledge on these clinically relevant phenomena. Accordingly, intensive research is necessary to develop new approaches in preventive dentistry.
牙釉质上的生物黏附及表面相互作用对于龋齿和牙侵蚀的起始、发展及预防至关重要。早期龋损和侵蚀性病变表面及内部的唾液蛋白可促进或加剧脱矿和再矿化。这适用于菌斑层、亚表面菌斑以及早期龋损内的蛋白质。对于这些与早期龋齿和牙侵蚀相关的蛋白质结构知之甚少。因此，为了开发限制和调节龋齿及牙侵蚀的新型制剂，非常需要了解牙齿表面与口腔之间界面处发生的潜在过程。目标与发现：本文阐述了目前关于牙齿表面与口腔液体界面处发生过程的知识。牙齿硬组织上的蛋白质层可预防或加剧脱矿过程，而早期侵蚀性或龋损内的蛋白质可能会显著阻碍再矿化并限制离子进入病变部位。
尽管有机 - 无机表面相互作用对于牙齿表面的脱矿和再矿化过程至关重要，但对于这些临床相关现象的了解有限。因此，开展深入研究以开发预防牙科的新方法很有必要。
