Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis.

The identification of biomarkers plays an important role in the diagnosis and prognosis of cancers. In this study, we explored the diagnostic and prognostic value of the expression across pan-cancer analysis from online databases (Oncomine, cBioPortal, Breast Cancer Gene-Expression Miner, UALCAN, GEO, BCIP, TNMplot, ENCORI, Kaplan-Meier Plotter, and LinkedOmics). We found that was overexpressed in a number of different kinds of cancers, especially in breast cancer, and higher expression level was associated with the HER+, p53 mutant, node-involved, NPI stage 3, basal-like, and triple-negative groups compared with the other subgroups of breast cancer. The expression levels were higher in patients that were 21-40 years old than those in patients of other ages and were higher in the African-American group than in the Caucasian group. We also analyzed the related microRNAs and their prognostic values in breast cancer. This study highlights the significance of in cancers and provides evidence for its potential as a biomarker for the diagnosis and prognosis of cancers.