血浆弹性蛋白、杀菌肽和α-防御素在儿童炎症性克罗恩病中升高，并反映疾病部位。
Plasma elafin, cathelicidin, and α-defensins are increased in paediatric inflammatory Crohn's disease and reflect disease location.
作者信息
Wędrychowicz Andrzej, Tomasik Przemysław, Kowalska-Duplaga Kinga, Pieczarkowski Stanisław, Fyderek Krzysztof
机构信息
Department of Paediatrics, Gastroenterology, and Nutrition, Jagiellonian University Medical College, Krakow, Poland.
Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
出版信息
Arch Med Sci. 2021 Jun 11;17(4):1114-1117. doi: 10.5114/aoms/138349. eCollection 2021.
INTRODUCTION
The aim of our study was to assess antimicrobial peptides in children with Crohn's disease (CD).
METHODS
Plasma elafin, cathelicidin, and α- and β-defensins were assessed in 35 children with CD using immunoassays. Phenotype and location of CD were assessed based on the results of endoscopic and radiological studies.
RESULTS
We found increased elafin, cathelicidin, and α-defensins in children with inflammatory phenotype as compared to stricturing and penetrating phenotypes of CD. Additionally, we found increased elafin and cathelicidin in colonic location and α-defensins in ileal CD locations.
CONCLUSIONS
Assessing antimicrobial peptides may be helpful in estimating of phenotype and location of CD lesions.
引言
我们研究的目的是评估克罗恩病（CD）患儿体内的抗菌肽。
方法
采用免疫分析法对35例CD患儿的血浆弹性蛋白、杀菌肽以及α-和β-防御素进行评估。根据内镜和放射学检查结果评估CD的表型和病变部位。
结果
我们发现，与CD的狭窄型和穿透型表型相比，炎症型表型患儿的弹性蛋白、杀菌肽和α-防御素水平升高。此外，我们发现结肠部位的弹性蛋白和杀菌肽增加，而回肠CD部位的α-防御素增加。
结论
评估抗菌肽可能有助于估计CD病变的表型和部位。
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