Słowińska-Solnica Krystyna, Pawlica-Gosiewska Dorota, Gawlik Katarzyna, Owczarek Danuta, Cibor Dorota, Pocztar Halina, Mach Tomasz, Solnica Bogdan
Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland.
Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Krakow, Poland.
Arch Med Sci. 2021 Jan 5;17(1):252-257. doi: 10.5114/aoms/130842. eCollection 2021.
The aim of our study was to evaluate the diagnostic characteristics of selected inflammatory markers and the results of multiplication of their concentrations in the diagnosis and assessment of Crohn's disease (CD) activity.
We studied 49 patients with CD and 31 healthy controls. The CD patients were assigned to subgroups with active and inactive disease based on the Crohn's Disease Activity Index score. Serum interleukins and C-reactive protein (CRP) were measured using immunoassays.
Serum CRP and interleukins: IL-6, IL-17A, IL-23 were significantly higher in the CD group than in controls, with the best diagnostic performance for IL-23. Only serum IL-6 and CRP were significantly higher in active than in inactive disease, with the better performance of CRP. Multiplication results did not perform better than individual multipliers.
Serum CRP may be useful in the assessment of CD activity and there is a need for introduction of IL-23 for the CD diagnosis.
我们研究的目的是评估所选炎症标志物的诊断特征及其浓度乘积结果在克罗恩病（CD）活动诊断和评估中的作用。
我们研究了49例CD患者和31名健康对照者。根据克罗恩病活动指数评分，将CD患者分为疾病活动组和非活动组。采用免疫分析法检测血清白细胞介素和C反应蛋白（CRP）。
CD组血清CRP以及白细胞介素IL-6、IL-17A、IL-23显著高于对照组，其中IL-23的诊断性能最佳。仅血清IL-6和CRP在活动期疾病中显著高于非活动期疾病，CRP的性能更佳。浓度乘积结果并不比单个标志物更好。
血清CRP可能有助于评估CD活动，并且有必要引入IL-23用于CD诊断。
