Gao Xiao-Peng, Dong Jie-Jie, Xie Tian, Guan Xiaoqing
Department of Gastrointestinal Surgery, Yuncheng Central Hospital, Yuncheng, China.
Department of Hepatopancreatobiliary Surgery, Yuncheng Central Hospital, Yuncheng, China.
Front Cell Dev Biol. 2021 Jul 16;9:695544. doi: 10.3389/fcell.2021.695544. eCollection 2021.
, a transmembrane mucin, plays important roles in epithelial renewal and differentiation. Recent studies suggest that has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and cancer tissues. The underlying features of across various cancer types may allow us to ensure appropriate treatment and patient monitoring. However, the contributions of to pan-cancer have not been well characterized. In this study, we investigated the expression pattern and prognostic value of across multiple databases. We further explored genomic and epigenetic alterations of , its association with proliferation and metastasis, and the correlation with immune infiltration in different cancers. Our results characterized the distinct expression profile and prognostic values of in pan-cancer. Through examining its association with genomic alteration, tumor proliferation, and metastasis, as well as tumor infiltration, we revealed multiple function effects of . may influence prognosis, proliferation, metastasis, and immune response in opposite directions. In conclusion, our findings suggested the necessity to more carefully evaluate as a biomarker and therapeutic target and develop the new antibodies for cancer detection and intervention.
一种跨膜粘蛋白，在上皮更新和分化中发挥重要作用。最近的研究表明，其与胰腺癌发病机制有关，且在各种正常组织和癌组织中表达。其在各种癌症类型中的潜在特征可能有助于我们确保适当的治疗和患者监测。然而，其对泛癌的贡献尚未得到充分表征。在本研究中，我们在多个数据库中研究了其表达模式和预后价值。我们进一步探讨了其基因组和表观遗传改变、与增殖和转移的关联以及与不同癌症中免疫浸润的相关性。我们的结果表征了其在泛癌中的独特表达谱和预后价值。通过研究其与基因组改变、肿瘤增殖和转移以及肿瘤浸润的关联，我们揭示了其多种功能作用。其可能在相反方向上影响预后、增殖、转移和免疫反应。总之，我们的发现表明有必要更仔细地评估其作为生物标志物和治疗靶点的作用，并开发用于癌症检测和干预的新型抗体。
