Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?

, a transmembrane mucin, plays important roles in epithelial renewal and differentiation. Recent studies suggest that has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and cancer tissues. The underlying features of across various cancer types may allow us to ensure appropriate treatment and patient monitoring. However, the contributions of to pan-cancer have not been well characterized. In this study, we investigated the expression pattern and prognostic value of across multiple databases. We further explored genomic and epigenetic alterations of , its association with proliferation and metastasis, and the correlation with immune infiltration in different cancers. Our results characterized the distinct expression profile and prognostic values of in pan-cancer. Through examining its association with genomic alteration, tumor proliferation, and metastasis, as well as tumor infiltration, we revealed multiple function effects of . may influence prognosis, proliferation, metastasis, and immune response in opposite directions. In conclusion, our findings suggested the necessity to more carefully evaluate as a biomarker and therapeutic target and develop the new antibodies for cancer detection and intervention.