Institute of Chemistry, Vietnam Academy of Science and Technology, Caugiay, Hanoi, Vietnam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Caugiay, Hanoi, Vietnam.
Nat Prod Res. 2023 Jan;37(1):77-84. doi: 10.1080/14786419.2021.1950717. Epub 2021 Aug 2.
Three new xanthones, garcimckeans A-C () were isolated from the methanol extract of the stems of (Clusiaceae). Their structures were established by extensive spectroscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds displayed weak cytotoxic activity toward KB, Lu, HepG2, and MCF7 cell lines using the MTT assay with IC values ranging from 71.03 ± 2.93 to 90.40 ± 7.13 µM compared to that of the positive control compound, ellipticine (IC: 1.22 ± 0.10 ∼ 2.44 ± 0.2 µM).
从 （Clusiaceae）的茎甲醇提取物中分离得到三种新的紫檀烷酮，即 garcimckeans A-C ()。通过广泛的光谱分析（HR-ESI-MS 和 1D 和 2D NMR）以及与文献报道的光谱数据进行比较，确定了它们的结构。化合物 对 KB、Lu、HepG2 和 MCF7 细胞系表现出较弱的细胞毒性活性，MTT 测定的 IC 值范围为 71.03 ± 2.93 至 90.40 ± 7.13 μM，与阳性对照化合物椭圆素（IC：1.22 ± 0.10 至 2.44 ± 0.2 μM）相比。
