Zou Deli, Liu Fangshen, Liu Lei, Xu Huarong, Li Dahong, Hua Huiming
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, And School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, PR China.
Phytochemistry. 2024 Jan;217:113898. doi: 10.1016/j.phytochem.2023.113898. Epub 2023 Oct 22.
Eight previously undescribed and seven known xanthones were isolated from the fruits of Garcinia pedunculata Roxb. The structures were identified by a variety of spectroscopic methods as well as by comparison with the literature. The isolates showed appreciable cytotoxicity against three human tumor cell lines (HepG2, A549, and MCF-7). Pedunculaxanthone G exhibited inhibitory activities with IC values of 12.41, 16.51, and 15.45 μM against the cancer cell lines and induced cell apoptosis in HepG2 cells.
