Kozhedub R G
Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Sep-Oct;37(5):860-5.
Changes of pyramidal tract (PT) response after short tetanization, similar to natural stimulation conditions, were analysed in unanaesthetized and nonimmobilized rabbits. PT response recording revealed a long-term (1 h and more) potentiation of monosynaptic neocortical reactions. Predominant better expressed and more preserved increase of synaptic (N) component provides evidence to the conjecture that the basic mechanism of the long-term potentiation consists in the rise of efficiency of excitatory synaptic connections. Less protracted and differently directed changes of D-component permit to consider that excitability change of neurones may be only an additional mechanism of the long-term potentiation. Such features of neocortical long-term potentiation were revealed as its low-frequency depression (at test stimuli repetition) and its spontaneous restoration after depression.
在未麻醉且未固定的兔子中，分析了类似于自然刺激条件下短强直刺激后锥体束（PT）反应的变化。PT反应记录显示单突触新皮质反应存在长期（1小时及以上）增强。突触（N）成分的主要更好表达和更多保留的增加为以下推测提供了证据，即长期增强的基本机制在于兴奋性突触连接效率的提高。D成分较不持久且方向不同的变化使得可以认为神经元兴奋性变化可能只是长期增强的一种附加机制。新皮质长期增强的这些特征表现为其低频抑制（在测试刺激重复时）以及抑制后的自发恢复。
