Kozhedub R G
Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences, USSR, [AN SSSR], Moscow.
Neurosci Behav Physiol. 1990 Jul-Aug;20(4):304-9. doi: 10.1007/BF01236323.
A temporal analysis of changes in the response of the pyramidal tract using a model of prolonged potentiation revealed the substantial role of the mechanism of the heightening of total excitability of the cell at the initial stage of the formation of trace processes (an analog of the "dominant") which apparently promote the greater strengthening of the underlying mechanism of the CR, namely, the increase in the efficiency of synaptic associations. In the development of a CR in response to the stimulation of two points of the cortex, the increase in cell excitability was more marked in those experiments in which reinforcement was supplemented by the stimulation of the lateral hypothalamus, stimulation eliciting an alimentary reaction. These data make it possible to consider membrane plasticity as a cortical mechanism of the motivational component of reinforcement, a mechanism determining the dominant properties of the stage of generalization of the CR.
利用长时程增强模型对锥体束反应变化进行的时间分析表明，在痕迹过程形成的初始阶段（类似于“优势兴奋灶”），细胞总体兴奋性增强机制发挥了重要作用，这显然促进了条件反射潜在机制的进一步强化，即突触联系效率的提高。在对皮层两点刺激形成条件反射的过程中，在那些用刺激下丘脑外侧补充强化的实验中，细胞兴奋性的增加更为显著，这种刺激会引发进食反应。这些数据使我们有可能将膜可塑性视为强化动机成分的皮层机制，这一机制决定了条件反射泛化阶段的优势特性。
