State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.
University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
Nano Lett. 2021 Aug 25;21(16):6764-6772. doi: 10.1021/acs.nanolett.1c01313. Epub 2021 Aug 3.
Magnetic-based theranostics feature a high efficiency, excellent tissue penetration, and minimal damage to normal tissues, are noninvasive, and are widely used in the diagnosis and therapy of clinical diseases. Herein, a conceptually novel magnetostrictive-piezoelectric nanocatalytic medicine (MPE-NCM) for tumor therapy is proposed by initiating an intratumoral magneto-driven and piezoelectric-catalyzed reaction using core-shell structured CoFeO-BiFeO magnetostrictive-piezoelectric nanoparticles (CFO-BFO NPs) under an alternating magnetic field. The CFO-BFO NPs catalyze the generation of cytotoxic reactive oxygen species (ROS): superoxide radicals (•O) and hydroxyl radicals (•OH). The simulation calculation demonstrates the highly controllable electric polarization, facilitating the above catalytic reactions under the magnetic stimulation. Both a detailed cell-level assessment and the tumor xenograft evaluation evidence the significant tumor eradication efficacy of MPE-NCM. This study proposes an original and novel magneto-responsive nanocatalytic modality for cancer therapy, which displays promising prospects for the future clinic translation owing to its excellent catalytic dynamic responsiveness, high therapeutic efficacy, and biosafety .
基于磁性的治疗策略具有高效、组织穿透性好、对正常组织损伤小、非侵入性等优点，广泛应用于临床疾病的诊断和治疗。本研究提出了一种概念新颖的磁致伸缩-压电纳米催化药物（MPE-NCM）用于肿瘤治疗，该药物通过在交变磁场下使用核壳结构的 CoFeO-BiFeO 磁致伸缩-压电纳米粒子（CFO-BFO NPs）引发肿瘤内的磁驱动和压电催化反应。CFO-BFO NPs 可以催化产生细胞毒性的活性氧（ROS）：超氧自由基（•O）和羟基自由基（•OH）。模拟计算表明，高度可控的电极化有利于在磁场刺激下进行上述催化反应。详细的细胞水平评估和肿瘤异种移植评估都证明了 MPE-NCM 具有显著的肿瘤消除效果。本研究提出了一种用于癌症治疗的原创性和新颖的磁响应纳米催化模式，由于其出色的催化动力学响应、高效的治疗效果和生物安全性，显示出了在未来临床转化方面的广阔前景。
