Cheng Chao-Chun, Chen Li-Ling, Tseng Guan-Jhong, Huang Jun-Xuan, Ting Yen-Jing, Chiang Po-Han
Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 30010, Taiwan(R.O.C.).
Adv Healthc Mater. 2025 Aug;14(20):e2500805. doi: 10.1002/adhm.202500805. Epub 2025 Jun 16.
Wireless neuromodulation using nanoparticles, offering minimally invasive alternatives to conventional deep brain stimulation (DBS) while reducing the risks associated with hardware implants, has gained significant traction over the past decade. Nevertheless, ensuring millisecond-scale wireless DBS for the precise temporal control of neuronal activity remains challenging. This study reports magnetic-driven torque-induced electrical stimulation (MagTIES), a torque-based magnetoelectric neuromodulation method. By utilizing magnetic nanodiscs to generate torque under alternating magnetic fields (AMFs), the MagTIES induces a piezoelectric effect in piezoelectric nanoparticles, thereby overcoming the limitations of traditional magnetostriction-based systems. With an AMF (50 mT at ≈10 Hz), the proposed approach triggers neuronal activity both in vitro and in vivo, specifically in the deep brain region of the amygdala, within milliseconds. Furthermore, MagTIES enables the fine-tuning of amygdala brain oscillations through the precise modulation of the AMF frequency. By combining high spatial and temporal precision with minimal invasiveness, MagTIES provides an innovative approach for advancing neuroscience research with potential applications in understanding neural circuits and developing innovative therapies.
利用纳米颗粒进行无线神经调节，为传统的深部脑刺激（DBS）提供了微创替代方案，同时降低了与硬件植入相关的风险，在过去十年中获得了显著关注。然而，确保毫秒级的无线DBS以精确控制神经元活动的时间仍然具有挑战性。本研究报告了磁驱动扭矩诱导电刺激（MagTIES），这是一种基于扭矩的磁电神经调节方法。通过利用磁性纳米盘在交变磁场（AMF）下产生扭矩，MagTIES在压电纳米颗粒中诱导压电效应，从而克服了传统基于磁致伸缩系统的局限性。在AMF（约10Hz时为50mT）作用下，该方法能在体外和体内，特别是在杏仁核的深部脑区，在数毫秒内触发神经元活动。此外，MagTIES能够通过精确调节AMF频率来微调杏仁核的脑振荡。通过将高空间和时间精度与最小侵入性相结合，MagTIES为推进神经科学研究提供了一种创新方法，在理解神经回路和开发创新疗法方面具有潜在应用。
