Department of Neurosurgery, Peking University People's Hospital, 11th Xizhimen South St, Beijing, 100044, China.
Department of Nuclear Medicine, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), No. 79 Kangning Road, Xiangzhou District, Zhuhai, 519000, Guangdong, China.
Sci Rep. 2021 Aug 3;11(1):15753. doi: 10.1038/s41598-021-95333-8.
To contribute to the understanding of the aetiology and pathogenesis of Meige syndrome, the metabolic networks of patients with Meige syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People's Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige syndrome. Clustering coefficients (Cps) (density threshold: 16-28%; P < 0.05) and shortest path lengths (Lps) (density threshold: 10-15%; P < 0.05) were higher in Meige syndrome patients than in healthy controls. Small-worldness was lower in Meige syndrome patients than in healthy controls, and centrality was significantly lower in the right superior occipital gyrus and pallidum and higher in the right thalamus. Hypometabolism in the globus pallidus and thalamus may indicate basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige syndrome, providing a possible explanation for the efficacy of deep brain stimulation (DBS) in improving symptoms. Meige syndrome patients had abnormal small-world properties. Centrality changes in the right pallidus and thalamus verified the important roles of these regions in the pathogenesis of Meige syndrome.
为了深入了解 Meige 综合征的病因和发病机制，我们采用 18F-氟代脱氧葡萄糖正电子发射断层扫描（18F-FDG-PET）脑葡萄糖代谢成像技术对 Meige 综合征患者的代谢网络进行了研究。2017 年 9 月至 2020 年 9 月，我们在北京大学人民医院神经外科招募了 50 名右利手、未经药物治疗的原发性 Meige 综合征患者和 50 名年龄和性别匹配的健康对照者参与本研究。我们采用代谢连接和图论分析方法，根据 18F-FDG-PET 图像来研究代谢网络差异。我们发现 Meige 综合征患者的左侧内苍白球和顶叶、右侧额叶和中央后回以及双侧丘脑和小脑存在葡萄糖代谢低下。与健康对照组相比，Meige 综合征患者的聚类系数（Cps）（密度阈值：16-28%；P<0.05）和最短路径长度（Lps）（密度阈值：10-15%；P<0.05）更高。Meige 综合征患者的小世界属性更低，右侧顶上回和苍白球的中心度显著降低，右侧丘脑的中心度显著升高。苍白球和丘脑的代谢低下可能表明基底节-丘脑皮质运动回路异常是 Meige 综合征的发病机制，这为深部脑刺激（DBS）改善症状的疗效提供了可能的解释。Meige 综合征患者存在异常的小世界属性。右侧苍白球和丘脑的中心度变化验证了这些区域在 Meige 综合征发病机制中的重要作用。
