Svigos Katerina, Yin Lu, Fried Lauren, Lo Sicco Kristen, Shapiro Jerry
The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, NY, USA.
Am J Clin Dermatol. 2021 Sep;22(5):681-692. doi: 10.1007/s40257-021-00630-7. Epub 2021 Aug 4.
Lichen planopilaris is a primary lymphocytic cicatricial alopecia that commonly presents with hair loss at the vertex or parietal scalp. Patients may also have associated scalp itching, burning or tenderness. Due to scarring, hair loss is typically permanent. The main goals of treatment are reducing symptoms and preventing disease progression and further hair loss. Currently, the literature has limited evidence on treatments for this difficult condition, and most available evidence is from case reports and case series. Furthermore, the evidence shows a varied response to therapy, with frequent reports of poor response. This article reviews the diagnosis of this rare disease, summarize the currently available treatments, and provide insights and practices from alopecia experts.
扁平苔藓性毛发角化病是一种原发性淋巴细胞性瘢痕性脱发，通常表现为头顶或顶叶头皮脱发。患者还可能伴有头皮瘙痒、灼痛或压痛。由于瘢痕形成，脱发通常是永久性的。治疗的主要目标是减轻症状，防止疾病进展和进一步脱发。目前，文献中关于这种疑难病症治疗的证据有限，大多数现有证据来自病例报告和病例系列。此外，证据显示对治疗的反应各不相同，经常有反应不佳的报道。本文回顾了这种罕见疾病的诊断方法，总结了目前可用的治疗方法，并提供了脱发专家的见解和实践经验。
