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老年择期脊柱和大关节置换手术患者的肥胖与围手术期结局。

Obesity and perioperative outcomes in older surgical patients undergoing elective spine and major arthroplasty surgery.

机构信息

University of California, Department of Anesthesia & Perioperative Care, San Francisco, CA, United States of America.

Virginia Tech, Center for Gerontology and Department of Statistics, Blacksburg, VA, United States of America.

出版信息

J Clin Anesth. 2021 Dec;75:110475. doi: 10.1016/j.jclinane.2021.110475. Epub 2021 Aug 2.

Abstract

STUDY OBJECTIVE

To determine whether obesity status is associated with perioperative complications, discharge outcomes and hospital length of stay in older surgical patients.

DESIGN

Secondary analysis of five independent study cohorts (N = 1262).

SETTING

An academic medical center between 2001 and 2017 in the United States.

PATIENTS

Patients aged 65 years or older who were scheduled to undergo elective spine, knee, or hip surgery with an expected hospital stay of at least 2 days.

MEASUREMENTS

Body mass index (BMI) was stratified as nonobese (BMI ≤ 30 kg/m), obesity class 1 (30 kg/m ≤ BMI < 35 kg/m) or obesity class 2-3 (BMI ≥ 35 kg/m). Primary outcomes included predefined intraoperative and postoperative complications, hospital length of stay (LOS), and discharge location. Univariate and multivariate logistic regression was performed.

MAIN RESULTS

Obesity status was not associated with intraoperative adverse events. However, obesity class 2-3 significantly increased the risk for postoperative complications (IRR 1.43, 95% CI 1.03-1.95, P = 0.03), hospital LOS (IRR 1.13, 95% CI 1.02-1.25, P = 0.02) and non-home discharge destination (OR 1.95, 95% CI 1.35-2.81, P < 0.001) after accounting for patient related factors and surgery type.

CONCLUSIONS

Obesity class 2-3 status has prognostic value in predicting an increased incidence of postoperative complications, increased hospital LOS, and non-home discharge location. These results have important clinical implications for preoperative informed consent and provide areas to target for care improvement for the older obese individual.

摘要

研究目的

确定肥胖状况是否与老年手术患者的围手术期并发症、出院结果和住院时间有关。

研究设计

对五个独立研究队列(N=1262)进行二次分析。

研究地点

美国一家学术医疗中心,时间为 2001 年至 2017 年。

研究对象

年龄在 65 岁及以上、计划接受择期脊柱、膝关节或髋关节手术且预计住院时间至少 2 天的患者。

测量方法

体重指数(BMI)分为非肥胖(BMI≤30kg/m)、肥胖 1 级(30kg/m≤BMI<35kg/m)或肥胖 2-3 级(BMI≥35kg/m)。主要结局包括预先设定的术中及术后并发症、住院时间(LOS)和出院地点。进行单变量和多变量逻辑回归分析。

主要结果

肥胖状况与术中不良事件无关。然而,肥胖 2-3 级显著增加了术后并发症的风险(IRR 1.43,95%CI 1.03-1.95,P=0.03)、住院时间(IRR 1.13,95%CI 1.02-1.25,P=0.02)和非家庭出院目的地(OR 1.95,95%CI 1.35-2.81,P<0.001),在考虑患者相关因素和手术类型后。

结论

肥胖 2-3 级与术后并发症发生率增加、住院时间延长和非家庭出院地点有关,具有预后价值。这些结果对术前知情同意具有重要的临床意义,并为老年肥胖患者的护理改善提供了目标领域。

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