Department of Dermatology, The Second Affiliated Hospital of Nantong University, Nantong, China.
Ann Palliat Med. 2021 Jul;10(7):7933-7941. doi: 10.21037/apm-21-1482.
Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous units which can affect the individual's physiological and psychological health. Abnormal growth of lipophilic anaerobic bacteria such as Propionibacterium acnes is reported to be a major factor in the development of acne. However, the relationship between skin microorganisms and acne has not been fully elucidated. Our study aimed to explore the microbial differences between patients with acne and healthy controls (HCs).
The study involved 16 participants diagnosed with acne vulgaris and 5 HCs. We collected skin microbe samples from the cheeks, brow, forehead, neck, chin, or chest of the participants with sterile cotton swabs depending on the location of the acne lesions. Cutaneous microbe samples from the participants were tested by 16s sequencing.
Patients with acne showed increased diversity of skin microbiota in their samples. OTU535601 (Lachnospiraceae), OTU4460604 (Clostridiales), OTU3217705 (Moraxellaceae), OTU1066814 (Prevotella), and OTU455671 (Lactococcus garvieae) were the top 5 most abundant species found in patients with acne but were not present in HCs. OTU423327 (Achromobacter), OTU4423360 (Stenotrophomonas), OTU993127 (Porphyromonas), OTU677680 (Prevotella), and OTU269901 (Pseudomonas) were the top 5 most abundant species in HCs but were not found in patients with acne.
The present study has analyzed and compared the diversity and abundance of microorganisms and the characteristics of the main pathogenic bacteria in patients with acne and HCs. Our findings indicate the importance of maintaining the skin's commensal microflora balance with the development of acne vulgaris.
痤疮是一种累及毛囊皮脂腺单位的慢性炎症性皮肤病，可影响个体的生理和心理健康。据报道，亲脂性厌氧菌痤疮丙酸杆菌的异常生长是痤疮发病的主要因素之一。然而，皮肤微生物与痤疮之间的关系尚未完全阐明。本研究旨在探讨痤疮患者与健康对照（HC）之间的微生物差异。
本研究纳入了 16 名痤疮患者和 5 名 HCs。我们使用无菌棉签根据痤疮病变的位置从参与者的脸颊、眉毛、额头、颈部、下巴或胸部采集皮肤微生物样本。对参与者的皮肤微生物样本进行 16s 测序检测。
痤疮患者的样本中皮肤微生物多样性增加。OTU535601（Lachnospiraceae）、OTU4460604（Clostridiales）、OTU3217705（Moraxellaceae）、OTU1066814（Prevotella）和 OTU455671（Lactococcus garvieae）是痤疮患者样本中最丰富的前 5 个物种，但在 HCs 中不存在。OTU423327（Achromobacter）、OTU4423360（Stenotrophomonas）、OTU993127（Porphyromonas）、OTU677680（Prevotella）和 OTU269901（Pseudomonas）是 HCs 中最丰富的前 5 个物种，但在痤疮患者中不存在。
本研究分析比较了痤疮患者和 HCs 中微生物的多样性和丰度以及主要致病菌的特征。我们的研究结果表明，在痤疮的发展过程中，维持皮肤共生微生物菌群平衡非常重要。
