Ramos Eva, López-Muñoz Francisco, Gil-Martín Emilio, Egea Javier, Álvarez-Merz Iris, Painuli Sakshi, Semwal Prabhakar, Martins Natália, Hernández-Guijo Jesús M, Romero Alejandro
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Faculty of Health Sciences, University Camilo José Cela, C/Castillo de Alarcón 49, Villanueva de la Cañada, 28692 Madrid, Spain.
Antioxidants (Basel). 2021 Jul 20;10(7):1152. doi: 10.3390/antiox10071152.
Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and therefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. In addition, focusing the therapeutic action on strengthening the host protection responses in critical phases of the infective cycle makes it likely that multi-tasking melatonin will provide multi-protection, maintaining its efficacy against the virus variants that are already emerging and will emerge as long as SARS-CoV-2 continues to circulate among us.
病毒感染是宿主正常生理机能中的一场剧烈动荡。当前的2019冠状病毒病（COVID-19）大流行也不例外，因此，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与其他任何入侵微生物一样，一旦病毒接触人体，就会引发全身性免疫反应。褪黑素是一种全身性的调节物质，不会忽视任何内稳态紊乱，因此会发挥其协同三联体（抗氧化、抗炎和免疫刺激支柱）的作用，以阻止SARS-CoV-2或任何其他内源性或外源性威胁的感染周期。在COVID-19中，SARS-CoV-2在体内的传播涉及加剧的氧化活性，因此会产生大量活性氧和氮物种（RONS）。褪黑素在其他呼吸道疾病的临床前和临床研究中广泛证明的有益作用，间接支持了将其作为当前大流行可能的保护剂的观点。此外，将治疗作用集中在加强感染周期关键阶段的宿主保护反应上，使得具有多种功能的褪黑素有可能提供多重保护，对已经出现以及只要SARS-CoV-2继续在我们中间传播就会出现的病毒变体保持其疗效。
