CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Small. 2022 Sep;18(37):e2203400. doi: 10.1002/smll.202203400. Epub 2022 Aug 15.
The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)-like nanozyme, acting as an essential part of the regulation of reactive oxygen species (ROS), has attracted extensive research interest in recent years. However, CAT-like nanozymes are not as well discussed as other nanozymes such as peroxidase (POD)-like nanozymes, etc. Compared with natural catalase or artificial CAT enzymes, CAT-like nanozymes have unique properties of low cost, size-dependent properties, high catalytic activity and stability, and easy surface modification, etc., which make them widely used in various fields, especially in tumor therapy and disease treatment. Consequently, there is a great requirement to make a systematic discussion on CAT-like nanozymes. In this review, some key aspects of CAT-like nanozymes are deeply summarized as: 1) Typical CAT-like nanozymes classified by different nanomaterials; 2) The catalytic mechanisms proposed by experimental and theoretical studies; 3) Extensive applications in regard to tumor therapy, cytoprotection and sensing. Therefore, it is prospected that this review will contribute to the further design of CAT-like nanozymes and optimize their applications with much higher efficiency than before.
纳米酶领域在过去十年中发展迅速。在各种氧化还原酶模拟物中，类过氧化氢酶（CAT）纳米酶作为活性氧（ROS）调节的重要组成部分，近年来引起了广泛的研究兴趣。然而，与过氧化物酶（POD）类纳米酶等其他纳米酶相比，类 CAT 纳米酶的讨论并不多。与天然过氧化氢酶或人工 CAT 酶相比，类 CAT 纳米酶具有成本低、尺寸依赖性、高催化活性和稳定性以及易于表面修饰等独特性质，使其在各个领域得到了广泛的应用，特别是在肿瘤治疗和疾病治疗方面。因此，非常需要对类 CAT 纳米酶进行系统的讨论。在这篇综述中，对类 CAT 纳米酶的一些关键方面进行了深入总结：1）按不同纳米材料分类的典型类 CAT 纳米酶；2）实验和理论研究提出的催化机制；3）在肿瘤治疗、细胞保护和传感方面的广泛应用。因此，预计这篇综述将有助于进一步设计类 CAT 纳米酶，并以比以前更高的效率优化其应用。
