Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA.
Department of Biology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada.
Nucleic Acids Res. 2021 Jan 8;49(D1):D461-D467. doi: 10.1093/nar/gkaa1004.
The Transporter Classification Database (TCDB; tcdb.org) is a freely accessible reference resource, which provides functional, structural, mechanistic, medical and biotechnological information about transporters from organisms of all types. TCDB is the only transport protein classification database adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) and now (October 1, 2020) consists of 20 653 proteins classified in 15 528 non-redundant transport systems with 1567 tabulated 3D structures, 18 336 reference citations describing 1536 transporter families, of which 26% are members of 82 recognized superfamilies. Overall, this is an increase of over 50% since the last published update of the database in 2016. This comprehensive update of the database contents and features include (i) adoption of a chemical ontology for substrates of transporters, (ii) inclusion of new superfamilies, (iii) a domain-based characterization of transporter families for the identification of new members as well as functional and evolutionary relationships between families, (iv) development of novel software to facilitate curation and use of the database, (v) addition of new subclasses of transport systems including 11 novel types of channels and 3 types of group translocators and (vi) the inclusion of many man-made (artificial) transmembrane pores/channels and carriers.
转运蛋白分类数据库（TCDB；tcdb.org）是一个免费获取的参考资源，提供了来自各种生物的转运蛋白的功能、结构、机制、医学和生物技术信息。TCDB 是国际生物化学与分子生物学联合会（IUBMB）唯一采用的转运蛋白分类数据库，目前（2020 年 10 月 1 日）包含 20653 种蛋白质，分为 15528 个非冗余转运系统，其中有 1567 个表格化的 3D 结构，18336 个参考文献描述了 1536 个转运蛋白家族，其中 26%是 82 个公认超家族的成员。自 2016 年数据库最后一次更新以来，这一数字增加了 50%以上。数据库内容和功能的全面更新包括：（i）采用转运蛋白底物的化学本体论；（ii）纳入新的超家族；（iii）基于结构域的转运蛋白家族特征描述，用于识别新成员以及家族之间的功能和进化关系；（iv）开发了新的软件，以促进数据库的管理和使用；（v）增加了新的转运系统子类，包括 11 种新型通道和 3 种基团转运蛋白；（vi）纳入了许多人工（合成）跨膜孔/通道和载体。
