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Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.迷走神经刺激联合康复治疗缺血性脑卒中后上肢运动功能（VNS-REHAB）：一项随机、盲法、关键性、设备试验。
Lancet. 2021 Apr 24;397(10284):1545-1553. doi: 10.1016/S0140-6736(21)00475-X.
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A method for calculating the fragility index of continuous outcomes.一种计算连续结局脆弱指数的方法。
J Clin Epidemiol. 2021 Aug;136:20-25. doi: 10.1016/j.jclinepi.2021.02.023. Epub 2021 Mar 5.
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Survival-Inferred Fragility Index of Phase 3 Clinical Trials Evaluating Immune Checkpoint Inhibitors.评估免疫检查点抑制剂的 3 期临床试验的生存推断脆弱指数。
JAMA Netw Open. 2020 Oct 1;3(10):e2017675. doi: 10.1001/jamanetworkopen.2020.17675.
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Fragility of clinical trials across research fields: A synthesis of methodological reviews.各研究领域临床试验的脆弱性：方法学综述的综合分析。
Contemp Clin Trials. 2020 Oct;97:106151. doi: 10.1016/j.cct.2020.106151. Epub 2020 Sep 15.
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The weakness of fragility index exposed in an analysis of the traumatic brain injury management guidelines: A meta-epidemiological and simulation study.脆弱指数的弱点在创伤性脑损伤管理指南分析中暴露无遗：一项荟萃流行病学和模拟研究。
PLoS One. 2020 Aug 18;15(8):e0237879. doi: 10.1371/journal.pone.0237879. eCollection 2020.
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Dismantling the Fragility Index: A demonstration of statistical reasoning.拆解脆弱指数：统计推理的演示。
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Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results.反向脆弱指数在统计学上无显著意义的随机临床试验结果中的应用。
JAMA Netw Open. 2020 Aug 3;3(8):e2012469. doi: 10.1001/jamanetworkopen.2020.12469.
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Calculation of the fragility index of randomized controlled trials in epilepsy published in twelve major journals.计算发表在 12 大期刊的癫痫随机对照试验的脆弱指数。
Epilepsy Res. 2020 Jan;159:106258. doi: 10.1016/j.eplepsyres.2019.106258. Epub 2019 Dec 17.
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Fragility index: how fragile is the data that support the American College of Gastroenterology guidelines for the management of Crohn's disease?脆性指数：支持美国胃肠病学院克罗恩病管理指南的数据有多脆弱？
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Fragility Index in Cardiovascular Randomized Controlled Trials.心血管随机对照试验中的脆弱性指数。
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The Fragility Index for Assessing the Robustness of the Statistically Significant Results of Experimental Clinical Studies.

作者信息

Ho Adrienne K

机构信息

Department of Thoracic Oncology, Wythenshawe Hospital, Manchester, UK.

Present address: Department of Public Health Sciences (Epidemiology), Queen's University, Kingston, Ontario, Canada.

出版信息

J Gen Intern Med. 2022 Jan;37(1):206-211. doi: 10.1007/s11606-021-06999-9. Epub 2021 Aug 6.

DOI:10.1007/s11606-021-06999-9
PMID:34357573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8739402/
Abstract
摘要