Luís Catarina, Algarra Manuel, Câmara José S, Perestrelo Rosa
CQM-Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal.
Faculdade de Ciências da Vida, Unidade de Ciências Médicas, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal.
Toxics. 2021 Jul 1;9(7):157. doi: 10.3390/toxics9070157.
Phthalates are a group of chemicals used in a multitude of important industrial products (e.g., medical devices, children's toys, and food packages), mainly as plasticizers to improve mechanical properties such as flexibility, transparency, durability, and longevity of polyvinyl chloride (PVC). The wide occurrence of phthalates in many consumer products, including foods (e.g., bottled water, soft drinks, wine, milk, and meat) brings that most people are exposed to phthalates every day, which raises some concerns. Adverse health outcomes from phthalates exposure have been associated with endocrine disruption, deformities in the human reproductive system, increased risk of preterm birth, carcinogen exposure, among others. Apprehension related to the health risks and ubiquitous incidence of phthalates in foods inspires the development of reliable analytical approaches that allow their detection and quantification at trace levels. The purpose of the current review is to provide information related to the presence of phthalates in the food chain, highlighting the health risks associated with their exposure. Moreover, an overview of emerging extraction procedures and high-resolution analytical approaches for a comprehensive quantification of phthalates is presented.
邻苯二甲酸盐是一类用于众多重要工业产品（如医疗设备、儿童玩具和食品包装）中的化学物质，主要用作增塑剂，以改善聚氯乙烯（PVC）的机械性能，如柔韧性、透明度、耐用性和寿命。邻苯二甲酸盐在许多消费品中广泛存在，包括食品（如瓶装水、软饮料、葡萄酒、牛奶和肉类），这使得大多数人每天都接触到邻苯二甲酸盐，引发了一些担忧。接触邻苯二甲酸盐产生的不良健康后果与内分泌紊乱、人类生殖系统畸形、早产风险增加、致癌物接触等有关。对食品中邻苯二甲酸盐的健康风险和普遍存在的担忧促使人们开发可靠的分析方法，以便在痕量水平上对其进行检测和定量。本综述的目的是提供与食物链中邻苯二甲酸盐存在相关的信息，突出与其接触相关的健康风险。此外，还概述了用于邻苯二甲酸盐全面定量的新兴提取程序和高分辨率分析方法。
