Al-Lahham Adnan, Khanfar Nashat, Albataina Noor, Al Shwayat Rana, Altwal Rawsan, Abulfeilat Talal, Alawneh Ghaith, Khurd Mohammad, Alqadi Altamimi Abdelsalam
Department of Biomedical Engineering, School of Applied Medical Sciences, German Jordanian University, Amman 11180, Jordan.
Pediatric Clinic, Khalda, Salim Khouri Str. 48, Amman 11953, Jordan.
Vaccines (Basel). 2021 Jul 14;9(7):789. doi: 10.3390/vaccines9070789.
A pneumococcal carriage surveillance study took place examining Jordanian children in urban and rural areas in the period 2015-2019.
To determine urban and rural differences in pneumococcal carriage rate, resistance, and serotypes among healthy Jordanian children from Amman (urban) and eastern Madaba (rural).
Nasopharyngeal swabs (NP) were taken from 682 children aged 1 to 163 months. Pneumococcal identification, serotyping, and resistance were performed according to standard method.
The number of cases tested for Amman was 267 and there were 415 cases tested for eastern Madaba. Carriage rate for eastern Madaba was 39.5% and 31.1% for Amman. Predominant serotypes for eastern Madaba and Amman were 19F (21.3%; 15.7%), 23F (12.2%; 9.6%), 14 (6.7%; 2.4%), 19A (4.9%; 2.4%), and 6A (5.5%; 3.6%). Resistance rates for eastern Madaba and Amman were as follows: penicillin (95.8%; 81.9%), clarithromycin (68.9%; 59.0%), clindamycin (40.8%; 31.3%), and trimethoprim-sulfamethoxazole (73.2%; 61.4%). Coverage of PCV7, PCV13, and the future PCV20 for Amman was 42.2%, 48.2%, and 60.2%; for eastern Madaba, coverage was 50.0%, 62.2%, and 73.2%, respectively. In Amman 25.8% of children received 1-3 PCV7 injections compared to 1.9% of children in eastern Madaba.
There were significant differences in carriage, resistance, and coverage between both regions. The potential inclusion of a PCV vaccination program for rural areas is essential.
2015年至2019年期间，开展了一项肺炎球菌携带情况监测研究，对约旦城乡地区的儿童进行了检查。
确定安曼（城市）和马达巴东部（农村）健康约旦儿童在肺炎球菌携带率、耐药性和血清型方面的城乡差异。
从682名年龄在1至163个月的儿童中采集鼻咽拭子。按照标准方法进行肺炎球菌鉴定、血清分型和耐药性检测。
安曼检测的病例数为267例，马达巴东部检测的病例数为415例。马达巴东部的携带率为39.5%，安曼为31.1%。马达巴东部和安曼的主要血清型为19F（21.3%；15.7%）、23F（12.2%；9.6%）及14（6.7%；2.4%）、19A（4.9%；2.4%）和6A（5.5%；3.6%）。马达巴东部和安曼的耐药率如下:青霉素（95.8%；81.9%）、克拉霉素（68.9%；59.0%）、克林霉素（40.8%；31.3%）和甲氧苄啶-磺胺甲恶唑（73.2%；61.4%）。安曼PCV7、PCV13及未来PCV20的覆盖率分别为42.2%、48.2%和60.2%；马达巴东部的覆盖率分别为50.0%、62.2%和73.2%。在安曼，25.8%的儿童接种了1 - 3剂PCV7，而马达巴东部只有1.9%的儿童接种。
两个地区在携带情况、耐药性和覆盖率方面存在显著差异。在农村地区推行肺炎球菌结合疫苗接种计划很有必要。
