Al-Lahham Adnan
Department of Biomedical Engineering, School of Applied Medical Sciences, German Jordanian University, Amman 11180, Jordan.
Vaccines (Basel). 2021 Nov 5;9(11):1283. doi: 10.3390/vaccines9111283.
is an opportunistic human-adapted pathogen driven by nasopharyngeal carriage.
To find the pneumococcal carriage rate, resistance, serotypes, and coverage of pneumococcal conjugate vaccines (PCVs) among infants in the first six months of age in the period from March 2008 to April 2016.
Nasopharyngeal swabs (NP) were taken from healthy infants from the northern part of Jordan. Swabs were processed for cultivation, identification, resistance testing and serotyping according to standard methods.
During the surveillance period, 484 infants of this age group were tested, with a total carriage rate of 56.2%. 96.2% of infants one to two months of age got one PCV7 injection and were 58% carriers at the time of the first injection. At age three to four months, 84.9% had received two injections, with a carriage rate of 54.9% at the time of the second injection. At ages five to six months, 12.5% had received one to three injections, with a carriage rate of 43.8%. Predominant serotypes in all age groups were 19F (12.5%), 6A (11.4%), 11A (8.4%), 19A (7.0%), 6B (6.6%), 23F (5.9%), 15B (5.1%), 15A and 23A (4.0% each). Coverage of PCV7, PCV13 and the future PCV20 among all cases were 30.5%, 50.7% and 70.6%, respectively. The highest coverage rate of 78.6% was noticed in the age group at five to six months with the future PCV20. Antibiotic resistance was the highest in the first age group.
Pneumococcal carriage starts from the first month of the infant's life. The highest coverage was noticed for PCV20, which implies the necessity for inoculation with future vaccines.
是一种由鼻咽部携带驱动的适应人类的机会致病菌。
确定2008年3月至2016年4月期间6个月龄以内婴儿的肺炎球菌携带率、耐药性、血清型以及肺炎球菌结合疫苗（PCV）的覆盖率。
从约旦北部的健康婴儿中采集鼻咽拭子（NP）。按照标准方法对拭子进行培养、鉴定、耐药性检测和血清分型。
在监测期间，对该年龄组的484名婴儿进行了检测，总携带率为56.2%。1至2个月龄的婴儿中有96.2%接种了一剂PCV7，首次接种时携带率为58%。3至4个月龄时，84.9%的婴儿接种了两剂，第二次接种时携带率为54.9%。5至6个月龄时，12.5%的婴儿接种了1至3剂，携带率为43.8%。所有年龄组中主要的血清型为19F（12.5%）、6A（11.4%）、11A（8.4%）、19A（7.0%）、6B（6.6%）、23F（5.9%）、15B（5.1%）、15A和23A（各4.0%）。所有病例中PCV7、PCV13和未来的PCV20的覆盖率分别为30.5%、50.7%和70.6%。在5至6个月龄组中，未来PCV20的覆盖率最高，为78.6%。抗生素耐药性在第一个年龄组中最高。
肺炎球菌携带始于婴儿出生后的第一个月。PCV20的覆盖率最高，这意味着接种未来疫苗的必要性。
