Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.
Department of Cardiology, Antwerp University Hospital, 2650 Edegem, Belgium.
Int J Environ Res Public Health. 2021 Jul 28;18(15):8004. doi: 10.3390/ijerph18158004.
Ectopic fat leads to metabolic health problems. This research aimed to assess the effectiveness of a hypocaloric diet intervention together with an unsupervised exercise training program in comparison with a hypocaloric diet alone to reduce ectopic fat deposition. Sixty-one premenopausal women with overweight or obesity participated in this controlled trial and were each randomised into either a usual care group (hypocaloric diet) or intervention group (hypocaloric diet + unsupervised exercise training). Ectopic fat deposition, metabolic parameters, incremental costs from a societal perspective and incremental quality-adjusted life years (QALYs) were assessed before, during and after the six-month intervention period. In the total sample, there was a significant decrease in visceral adipose tissue (VAT: -18.88 cm, 95% CI -11.82 to -25.95), subcutaneous abdominal adipose tissue (SAT: -46.74 cm, 95% CI -29.76 to -63.18), epicardial fat (ECF: -14.50 cm, 95% CI -10.9 to -18.98) and intrahepatic lipid content (IHL: -3.53%, 95% CI -1.72 to -5.32). Consequently, an "adapted" economic analysis revealed a non-significant decrease in costs and an increase in QALYs after the intervention. No significant differences were found between groups. A multidisciplinary lifestyle approach seems successful in reducing ectopic fat deposition and improving the metabolic risk profile in women with overweight and obesity. The addition of unsupervised exercise training did not further improve the metabolic health or phenotype over the six months.
异位脂肪会导致代谢健康问题。本研究旨在评估低热量饮食干预与非监督运动训练方案相结合与单纯低热量饮食相比，减少异位脂肪沉积的效果。61 名超重或肥胖的绝经前妇女参与了这项对照试验，每个人都被随机分为常规护理组（低热量饮食）或干预组（低热量饮食+非监督运动训练）。在六个月的干预期间之前、期间和之后，评估异位脂肪沉积、代谢参数、从社会角度计算的增量成本和增量质量调整生命年（QALY）。在总样本中，内脏脂肪组织（VAT：-18.88cm，95%CI-11.82 至-25.95）、腹部皮下脂肪组织（SAT：-46.74cm，95%CI-29.76 至-63.18）、心外膜脂肪（ECF：-14.50cm，95%CI-10.9 至-18.98）和肝内脂质含量（IHL：-3.53%，95%CI-1.72 至-5.32）均显著减少。因此，“适应性”经济分析显示，干预后成本略有降低，QALY 略有增加，但无统计学意义。组间无显著差异。多学科生活方式方法似乎成功地减少了超重和肥胖女性的异位脂肪沉积，并改善了代谢风险状况。在六个月内，非监督运动训练的加入并没有进一步改善代谢健康或表型。
