Hoogkamp-Korstanje J A
Laboratory for Public Health, Leeuwarden.
Drugs. 1987;34 Suppl 1:134-8. doi: 10.2165/00003495-198700341-00029.
The in vitro susceptibility of 135 strains of Yersinia enterocolitica was tested by agar dilution. About 85% of the strains were susceptible to trimethoprim (1 mg/L), tetracycline (4 mg/L), chloramphenicol (4 mg/L) and cefuroxime (8 mg/L); 90 to 100% to piperacillin (16 mg/L), cefotaxime (8 mg/L) and gentamicin (1 mg/L); 100% to ciprofloxacin (less than or equal to 0.016 mg/L), ofloxacin (0.06 mg/L) and pefloxacin (0.12 mg/L). The outcome of 88 patients, treated for various forms of yersiniosis, showed 15% failure for trimethoprim or co-trimoxazole and tetracycline and 70% failure for cephalosporins and aminoglycoside-beta-lactam combinations. Four patients were successfully treated with ciprofloxacin 500 mg orally or 300 mg intravenously administered twice daily for up to 6 weeks.
采用琼脂稀释法检测了135株小肠结肠炎耶尔森菌的体外药敏情况。约85%的菌株对甲氧苄啶（1mg/L）、四环素（4mg/L）、氯霉素（4mg/L）和头孢呋辛（8mg/L）敏感；90%至100%的菌株对哌拉西林（16mg/L）、头孢噻肟（8mg/L）和庆大霉素（1mg/L）敏感；100%的菌株对环丙沙星（≤0.016mg/L）、氧氟沙星（0.06mg/L）和培氟沙星（0.12mg/L）敏感。88例接受不同形式耶尔森菌病治疗的患者中，甲氧苄啶或复方新诺明以及四环素治疗失败率为15%，头孢菌素和氨基糖苷类-β-内酰胺类联合治疗失败率为70%。4例患者通过口服500mg环丙沙星或静脉注射300mg环丙沙星，每日两次，持续治疗长达6周，治疗成功。
