Baskin David S, Sharpe Martyn A, Nguyen Lisa, Helekar Santosh A
Kenneth R. Peak Brain and Pituitary Tumor Treatment Center, Department of Neurosurgery, Houston Methodist Neurological Institute, Houston, TX, United States.
Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, United States.
Front Oncol. 2021 Jul 22;11:708017. doi: 10.3389/fonc.2021.708017. eCollection 2021.
Alternating electric field therapy has been approved for glioblastoma (GBM). We have preclinical evidence for anticancer effects in GBM cell cultures and mouse xenografts with an oscillating magnetic field (OMF) generating device. Here we report OMF treatment of end-stage recurrent glioblastoma in a 53-year-old man who had undergone radical surgical excision and chemoradiotherapy, and experimental gene therapy for a left frontal tumor. He experienced tumor recurrence and progressive enlargement with leptomeningeal involvement. OMF for 5 weeks was well tolerated, with 31% reduction of contrast-enhanced tumor volume and reduction in abnormal T2-weighted Fluid-Attenuated Inversion Recovery volume. Tumor shrinkage appeared to correlate with treatment dose. These findings suggest a powerful new noninvasive therapy for glioblastoma.
交变电场疗法已被批准用于治疗胶质母细胞瘤（GBM）。我们有临床前证据表明，在胶质母细胞瘤细胞培养物和带有振荡磁场（OMF）发生装置的小鼠异种移植模型中，该疗法具有抗癌作用。在此，我们报告了一名53岁男性终末期复发性胶质母细胞瘤患者接受OMF治疗的情况。该患者曾接受根治性手术切除、放化疗以及针对左侧额叶肿瘤的实验性基因治疗。他出现了肿瘤复发且肿瘤逐渐增大，并伴有软脑膜受累。接受5周的OMF治疗后，患者耐受性良好，增强扫描肿瘤体积减少了31%，T2加权液体衰减反转恢复序列异常体积也有所减小。肿瘤缩小似乎与治疗剂量相关。这些发现提示OMF可能是一种强有力的新型胶质母细胞瘤无创治疗方法。
