Liu Yinlong, Tang Qisheng, Tao Quan, Dong Hui, Shi Zhifeng, Zhou Liangfu
Department of Neurosurgery, Huashan Hospital, Fudan University, China.
Department of Neurosurgery, Huashan Hospital, Fudan University, China; National Center for Neurological Disorders, China; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, China; Neurosurgical Institute of Fudan University, Shanghai, China; Shanghai Clinical Medical Center of Neurosurgery, China.
J Adv Res. 2025 Mar;69:531-543. doi: 10.1016/j.jare.2024.03.024. Epub 2024 Mar 31.
Glioblastoma (GBM) is the most common malignant tumour of the central nervous system. Despite recent advances in multimodal GBM therapy incorporating surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy), and supportive care, the overall survival (OS) remains poor, and long-term survival is rare. Currently, the primary obstacles hindering the effectiveness of GBM treatment are still the blood-brain barrier and tumor heterogeneity. In light of its substantial advantages over conventional therapies, such as strong penetrative ability and minimal side effects, low-frequency magnetic fields (LF-MFs) therapy has gradually caught the attention of scientists.
In this review, we shed the light on the current status of applying LF-MFs in the treatment of GBM. We specifically emphasize our current understanding of the mechanisms by which LF-MFs mediate anticancer effects and the challenges faced by LF-MFs in treating GBM cells. Furthermore, we discuss the prospective applications of magnetic field therapy in the future treatment of GBM. Key scientific concepts of review: The review explores the current progress on the use of LF-MFs in the treatment of GBM with a special focus on the potential underlying mechanisms of LF-MFs in anticancer effects. Additionally, we also discussed the complex magnetic field features and biological characteristics related to magnetic bioeffects. Finally, we proposed a promising magnetic field treatment strategy for future applications in GBM therapy.
胶质母细胞瘤（GBM）是中枢神经系统最常见的恶性肿瘤。尽管在将手术、放疗、全身治疗（化疗、靶向治疗）和支持治疗相结合的多模式GBM治疗方面取得了最新进展，但总体生存率（OS）仍然很差，长期生存罕见。目前，阻碍GBM治疗有效性的主要障碍仍然是血脑屏障和肿瘤异质性。鉴于低频磁场（LF-MFs）疗法相对于传统疗法具有显著优势，如穿透能力强和副作用小，它已逐渐引起科学家的关注。
在本综述中，我们阐述了LF-MFs在GBM治疗中的应用现状。我们特别强调了目前对LF-MFs介导抗癌作用机制的理解以及LF-MFs在治疗GBM细胞时面临的挑战。此外，我们还讨论了磁场疗法在未来GBM治疗中的潜在应用。综述的关键科学概念：本综述探讨了LF-MFs在GBM治疗中的当前进展，特别关注LF-MFs抗癌作用的潜在机制。此外，我们还讨论了与磁生物效应相关的复杂磁场特征和生物学特性。最后，我们提出了一种有前景的磁场治疗策略，以供未来在GBM治疗中应用。
