Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
ACS Appl Bio Mater. 2021 Sep 20;4(9):7081-7093. doi: 10.1021/acsabm.1c00694. Epub 2021 Aug 19.
To date, various Prussian blue analogues (PBAs) have been prepared for biomedical applications due to their unique structural advantages. However, the safety and effectiveness of tumor treatment still need further exploration. This contribution reports a facile synthesis of PBA with superior tumor synergetic therapeutic effects and a detailed mechanistic evaluation of their intrinsic tumor metastasis inhibition activity. The as-synthesized PBA has a uniform cube structure with a diameter of approximately 220 nm and shows high near-infrared light (NIR) photoreactivity, photothermal conversion efficiency (41.44%), and photodynamic effect. Additionally, PBA could lead to a chemodynamic effect, which is caused by the Fenton reaction and ferroptosis. The combined therapy strategy of PBA exhibits notable tumor ablation properties due to photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) effects without obvious toxicity . The PBA has also shown potential as a contrast agent for magnetic resonance imaging (MRI) and photoacoustic (PA) imaging. More importantly, careful investigations reveal that PBA displays excellent biodegradation and anti-metastasis properties. Further exploration of the PBA implies that its underlying mechanism of intrinsic tumor metastasis inhibition activity can be attributed to the modulation of epithelial-mesenchymal transition (EMT) expression. The considerable potential exhibited by the as-synthesized PBA makes it an ideal candidate as a synergetic therapeutic agent for tumor treatment.
迄今为止，由于普鲁士蓝类似物（PBAs）具有独特的结构优势，已被用于生物医学应用。然而，肿瘤治疗的安全性和有效性仍需要进一步探索。本研究报道了一种简便的 PBA 合成方法，其具有优异的肿瘤协同治疗效果，并对其内在的肿瘤转移抑制活性进行了详细的机制评估。合成的 PBA 具有均匀的立方结构，直径约为 220nm，具有高光近红外（NIR）光反应性、光热转换效率（41.44%）和光动力效应。此外，PBA 可以引发芬顿反应和铁死亡等化学动力学效应。由于光热治疗（PTT）/光动力治疗（PDT）/化学动力学治疗（CDT）的协同治疗策略，PBA 表现出显著的肿瘤消融特性，而没有明显的毒性。PBA 还显示出作为磁共振成像（MRI）和光声（PA）成像的造影剂的潜力。更重要的是，仔细的研究表明，PBA 具有优异的生物降解性和抗转移特性。对 PBA 的进一步研究表明，其内在的肿瘤转移抑制活性的机制可以归因于上皮-间充质转化（EMT）表达的调节。所合成的 PBA 具有很大的潜力，使其成为肿瘤治疗的理想协同治疗剂。
