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广藿香醇通过脊髓损伤后Akt/CHOP/半胱天冬酶-3通路抑制内质网应激来改善血脊髓屏障的完整性。

Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury.

作者信息

Huang Chongan, Zhang Weiqi, Chu FeiFan, Qian Hao, Wang Yining, Qi Fangzhou, Ye Mengke, Zhou Jiaying, Lin Zhi, Dong ChenLin, Wang Xiangyang, Wang Qingqing, Jin Haiming

机构信息

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.

出版信息

Front Cell Dev Biol. 2021 Jul 22;9:693533. doi: 10.3389/fcell.2021.693533. eCollection 2021.

DOI:10.3389/fcell.2021.693533
PMID:34368142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8339579/
Abstract

Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis . Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.

摘要

脊髓损伤（SCI）是一种中枢神经系统（CNS）的破坏性复杂疾病，目前尚无临床治疗方法。血脊髓屏障（BSCB）破裂是SCI中的一个关键事件，会加重神经损伤。因此，维持BSCB的完整性可能是治疗SCI的一种潜在方法。在此，我们表明广藿香醇（PA）对SCI具有保护作用。我们发现PA通过减少紧密连接（TJ）和内皮细胞的损失，显著防止了BSCB的高通透性。PA还抑制了内质网应激和细胞凋亡。此外，在SCI大鼠模型中，PA有效改善了神经功能缺损。总体而言，这些结果证明PA通过维持BSCB完整性发挥神经保护作用，因此有望成为SCI治疗的候选药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/769f3c3718bf/fcell-09-693533-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/60023d0a5acb/fcell-09-693533-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/00930397a730/fcell-09-693533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/f985c37caa07/fcell-09-693533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/da9bce56f82a/fcell-09-693533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/52bd58e42204/fcell-09-693533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/769f3c3718bf/fcell-09-693533-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/60023d0a5acb/fcell-09-693533-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/b57db99a52e8/fcell-09-693533-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/02cbed52353b/fcell-09-693533-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/00930397a730/fcell-09-693533-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/f985c37caa07/fcell-09-693533-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/da9bce56f82a/fcell-09-693533-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/52bd58e42204/fcell-09-693533-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c4d/8339579/769f3c3718bf/fcell-09-693533-g008.jpg

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