Aiello Eleonora M, Deshpande Sunil, Ozaslan Basak, Wolkowicz Kelilah L, Dassau Eyal, Pinsker Jordan E, Doyle Francis J
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, 150 Western Avenue, Boston, Massachusetts 02134, USA.
Sansum Diabetes Research Institute, Santa Barbara, CA.
Curr Opin Biomed Eng. 2021 Sep;19. doi: 10.1016/j.cobme.2021.100312. Epub 2021 Jun 18.
Automated insulin delivery (AID) systems have proven safe and effective in improving glycemic outcomes in individuals with type 1 diabetes (T1D). Clinical evaluation of this technology has progressed to large randomized, controlled outpatient studies and recent commercial approval of AID systems for children and adults. However, several challenges remain in improving these systems for different subpopulations (e.g., young children, athletes, pregnant women, seniors and those with hypoglycemia unawareness). In this review, we highlight the requirements and challenges in AID design for selected subpopulations, and discuss current advances from recent clinical studies.
自动胰岛素输送(AID)系统已被证明在改善1型糖尿病(T1D)患者的血糖结果方面是安全有效的。这项技术的临床评估已进展到大型随机对照门诊研究,并且AID系统最近已获得儿童和成人使用的商业批准。然而,在针对不同亚人群(如幼儿、运动员、孕妇、老年人以及低血糖无意识者)改进这些系统方面,仍存在一些挑战。在本综述中,我们强调了针对特定亚人群的AID设计要求和挑战,并讨论了近期临床研究的当前进展。