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英国一家医院中,在高疫苗接种率人群中发生的医院内麻疹暴发。

Nosocomial outbreak of measles amongst a highly vaccinated population in an English hospital setting.

作者信息

Berry L, Palmer T, Wells F, Williams E, Sibal B, Timms J

机构信息

University Hospital Coventry and Warwickshire NHS Trust Coventry, United Kingdom.

Communicable Disease Control, West Midlands Health Protection Team, Public Health England, Birmingham, United Kingdom.

出版信息

Infect Prev Pract. 2019 Aug 17;1(2):100018. doi: 10.1016/j.infpip.2019.100018. eCollection 2019 Jun.

DOI:10.1016/j.infpip.2019.100018
PMID:34368679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8336304/
Abstract

In May 2017 a patient attended the emergency department at a hospital in England, with a presumed allergic reaction. He was subsequently diagnosed with measles. There were seven further confirmed cases, five of whom had received two doses of MMR vaccine. This outbreak highlights the importance of not relying on vaccination status to rule out the diagnosis of measles. Epidemiological investigations of this outbreak were particularly challenging due to the highly infectious nature of the measles virus, and prevented full elucidation of either the source of this outbreak or the transmission pathways.

摘要

2017年5月,一名患者前往英国一家医院的急诊科就诊,疑似过敏反应。随后他被诊断出患有麻疹。又有7例确诊病例,其中5人已接种两剂麻疹、腮腺炎和风疹(MMR)疫苗。此次疫情凸显了不能仅依靠疫苗接种情况来排除麻疹诊断的重要性。由于麻疹病毒具有高度传染性,此次疫情的流行病学调查极具挑战性,阻碍了对疫情源头或传播途径的全面查明。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc44/8336304/80f194bacb42/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc44/8336304/fe8ab516d8fe/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc44/8336304/80f194bacb42/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc44/8336304/fe8ab516d8fe/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc44/8336304/80f194bacb42/gr2.jpg

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本文引用的文献

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Lancet Infect Dis. 2019 Apr;19(4):362-363. doi: 10.1016/S1473-3099(19)30129-X. Epub 2019 Mar 27.
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Measles and rubella elimination in the WHO Region for Europe: progress and challenges.世界卫生组织欧洲区域消除麻疹和风疹:进展与挑战
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Persistence of measles, mumps, and rubella antibodies in an MMR-vaccinated cohort: a 20-year follow-up.MMR疫苗接种队列中麻疹、腮腺炎和风疹抗体的持久性:20年随访
J Infect Dis. 2008 Apr 1;197(7):950-6. doi: 10.1086/528993.