Graduate School of Environmental & Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Higashi-ku, Kumamoto 862-8502, Japan.
Department of Nutrition and Metabolism, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan.
Nutrients. 2021 Jul 15;13(7):2424. doi: 10.3390/nu13072424.
To examine whether mild early time-restricted eating (eating dinner at 18:00 vs. at 21:00) improves 24-h blood glucose levels and postprandial lipid metabolism in healthy adults. Twelve participants (2 males and 10 females) were included in the study. In this 3-day (until the morning of day 3) randomized crossover study, two different conditions were tested: eating a late dinner (at 21:00) or an early dinner (at 18:00). During the experimental period, blood glucose levels were evaluated by each participant wearing a continuous blood glucose measuring device. Metabolic measurements were performed using the indirect calorimetry method on the morning of day 3. The study was conducted over three days; day 1 was excluded from the analysis to adjust for the effects of the previous day's meal, and only data from the mornings of days 2 and 3 were used for the analysis. Significant differences were observed in mean 24-h blood glucose levels on day 2 between the two groups ( = 0.034). There was a significant decrease in the postprandial respiratory quotient 30 min and 60 min after breakfast on day 3 in the early dinner group compared with the late dinner group ( < 0.05). Despite a difference of only 3 h, eating dinner early (at 18:00) has a positive effect on blood glucose level fluctuation and substrate oxidation compared with eating dinner late (at 21:00).
观察轻度限时进食（晚餐时间分别为 18:00 和 21:00）是否能改善健康成年人的 24 小时血糖水平和餐后脂质代谢。
本研究共纳入 12 名参与者（2 名男性和 10 名女性），采用 3 天（直至第 3 天早晨）随机交叉研究，分别测试 2 种不同条件：晚餐时间为 21:00（晚进食组）或 18:00（早进食组）。在实验期间，每位参与者均佩戴连续血糖监测仪评估血糖水平。第 3 天早晨采用间接测热法进行代谢测量。本研究共进行 3 天，第 1 天的数据被排除，以消除前一天饮食的影响，仅使用第 2 天和第 3 天早晨的数据进行分析。
与晚进食组相比，早进食组在第 2 天的 24 小时平均血糖水平存在显著差异（ = 0.034）。早进食组在第 3 天早餐后 30 分钟和 60 分钟时的餐后呼吸商显著降低（ < 0.05）。
尽管晚餐时间仅相差 3 小时，但与晚餐时间晚（21:00）相比，早（18:00）进食对血糖波动和底物氧化有积极影响。
