MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham Medical School, Nottingham, United Kingdom.
School of Life Sciences, University of Nottingham Medical School, Nottingham, United Kingdom.
Am J Clin Nutr. 2020 Oct 1;112(4):1015-1028. doi: 10.1093/ajcn/nqaa192.
Altering the temporal distribution of energy intake (EI) and introducing periods of intermittent fasting (IF) exert important metabolic effects. Restricting EI to earlier in the day [early time-restricted feeding (eTRF)] is a novel type of IF.
We assessed the chronic effects of eTRF compared with an energy-matched control on whole-body and skeletal muscle insulin and anabolic sensitivity.
Sixteen healthy males (aged 23 ± 1 y; BMI 24.0 ± 0.6 kg·m-2) were assigned to 2 groups that underwent either 2 wk of eTRF (n = 8) or control/caloric restriction (CON:CR; n = 8) diet. The eTRF diet was consumed ad libitum and the intervention was conducted before the CON:CR, in which the diet was provided to match the reduction in EI and body weight observed in eTRF. During eTRF, daily EI was restricted to between 08:00 and 16:00, which prolonged the overnight fast by ∼5 h. The metabolic responses to a carbohydrate/protein drink were assessed pre- and post-interventions following a 12-h overnight fast.
When compared with CON:CR, eTRF improved whole-body insulin sensitivity [between-group difference (95% CI): 1.89 (0.18, 3.60); P = 0.03; η2p = 0.29] and skeletal muscle uptake of glucose [between-group difference (95% CI): 4266 (261, 8270) μmol·min-1·kg-1·180 min; P = 0.04; η2p = 0.31] and branched-chain amino acids (BCAAs) [between-group difference (95% CI): 266 (77, 455) nmol·min-1·kg-1·180 min; P = 0.01; η2p = 0.44]. eTRF caused a reduction in EI (∼400 kcal·d-1) and weight loss (-1.04 ± 0.25 kg; P = 0.01) that was matched in CON:CR (-1.24 ± 0.35 kg; P = 0.01).
Under free-living conditions, eTRF improves whole-body insulin sensitivity and increases skeletal muscle glucose and BCAA uptake. The metabolic benefits of eTRF are independent of its effects on weight loss and represent chronic adaptations rather than the effect of the last bout of overnight fast. This trial was registered at clinicaltrials.gov as NCT03969745.
改变能量摄入的时间分布（EI）并引入间歇性禁食（IF）期会产生重要的代谢效应。将 EI 限制在一天的早期[限时进食（eTRF）]是一种新的 IF 类型。
我们评估了 eTRF 与能量匹配的对照相比对全身和骨骼肌胰岛素和合成代谢敏感性的慢性影响。
16 名健康男性（年龄 23 ± 1 岁；BMI 24.0 ± 0.6 kg·m-2）被分配到 2 组，分别进行 2 周的 eTRF（n = 8）或对照/热量限制（CON：CR；n = 8）饮食。eTRF 饮食随意进食，干预措施在 CON：CR 之前进行，其中饮食提供与 eTRF 观察到的 EI 减少和体重减轻相匹配。在 eTRF 期间，每日 EI 限制在 08:00 至 16:00 之间，这将夜间禁食延长了约 5 小时。在 12 小时禁食过夜后，在干预前后评估碳水化合物/蛋白质饮料对代谢的反应。
与 CON：CR 相比，eTRF 改善了全身胰岛素敏感性[组间差异（95%CI）：1.89（0.18，3.60）；P = 0.03；η2p = 0.29]和骨骼肌对葡萄糖[组间差异（95%CI）：4266（261，8270）μmol·min-1·kg-1·180 min；P = 0.04；η2p = 0.31]和支链氨基酸（BCAA）[组间差异（95%CI）：266（77，455）nmol·min-1·kg-1·180 min；P = 0.01；η2p = 0.44]的摄取。eTRF 导致 EI 减少（约 400 kcal·d-1）和体重减轻（-1.04 ± 0.25 kg；P = 0.01），这在 CON：CR 中是匹配的（-1.24 ± 0.35 kg；P = 0.01）。
在自由生活条件下，eTRF 提高了全身胰岛素敏感性，并增加了骨骼肌葡萄糖和 BCAA 的摄取。eTRF 的代谢益处独立于其对体重减轻的影响，代表了慢性适应，而不是最后一次过夜禁食的影响。该试验在 clinicaltrials.gov 上注册为 NCT03969745。
