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基于贝塞尔曲线的三维壳聚糖基气凝胶纤维结构的元胞自动机建模

Cellular Automata Modeling of Three-Dimensional Chitosan-Based Aerogels Fiberous Structures with Bezier Curves.

作者信息

Lebedev Igor, Lovskaya Daria, Mochalova Maria, Mitrofanov Igor, Menshutina Natalia

机构信息

Science and Education Center for Transfer of Biopharmaceutical Technologies, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.

出版信息

Polymers (Basel). 2021 Jul 30;13(15):2511. doi: 10.3390/polym13152511.

DOI:10.3390/polym13152511
PMID:34372113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8348900/
Abstract

In this work, a cellular automata approach was investigated for modeling three-dimensional fibrous nanoporous aerogel structures. A model for the generation of fibrous structures using the Bezier curves is proposed. Experimental chitosan-based aerogel particles were obtained for which analytical studies of the structural characteristics were carried out. The data obtained were used to generate digital copies of chitosan-based aerogel structures and to assess the accuracy of the developed model. The obtained digital copies of chitosan-based aerogel structures will be used to create digital copies of aerogel structures with embedded active pharmaceutical ingredients (APIs) and further predict the release of APIs from these structures.

摘要

在这项工作中，研究了一种细胞自动机方法来模拟三维纤维状纳米多孔气凝胶结构。提出了一种使用贝塞尔曲线生成纤维结构的模型。制备了基于壳聚糖的实验性气凝胶颗粒，并对其结构特征进行了分析研究。所得数据用于生成基于壳聚糖的气凝胶结构的数字副本，并评估所开发模型的准确性。所得基于壳聚糖的气凝胶结构的数字副本将用于创建含有嵌入式活性药物成分（API）的气凝胶结构的数字副本，并进一步预测API从这些结构中的释放情况。

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